Results 181 to 190 of about 4,121,048 (281)

Dissecting the Mechanism of (<i>R</i>)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry. [PDF]

ACS Catal, 2020
Machado TFG, Purg M, McMahon SA, Read BJ, Oehler V, Åqvist J, Gloster TM, da Silva RG.   +7 more
europepmc   +1 more source

Iterative phase retrieval in macromolecular crystal diffraction using the gradients of intensities

Journal of Applied Crystallography, EarlyView.
Incorporating molecular intensity gradients into an iterative projection algorithm enables model‐free electron‐density reconstruction even for low‐solvent macromolecular crystals.Iterative phase retrieval (IPR) offers a model‐independent route to crystallographic structure determination but is fundamentally limited by the sampling of the diffraction ...
Sebastian Bielfeldt, Oleksandr Yefanov, Matthias Mnich, Henry N. Chapman   +3 more
wiley   +1 more source

TorchRef: an open‐source PyTorch framework for crystallographic refinement

Journal of Applied Crystallography, EarlyView.
TorchRef is an open‐source PyTorch‐based crystallographic refinement framework that exposes all refinable parameters to automatic differentiation, accelerates structure factor evaluation by about two orders of magnitude on a GPU and enables novel workflows such as direct refinement against amplitude differences in time‐resolved crystallography ...
Hans-Peter Seidel, Jörg Standfuss, Tobias Weinert   +2 more
wiley   +1 more source

Deep learning applications in protein crystallography. [PDF]

Acta Crystallogr A Found Adv
Matinyan S, Filipcik P, Abrahams JP.
europepmc   +1 more source

Correlative X‐ray imaging and fluorescence microscopy in hydrated environments

Journal of Synchrotron Radiation, EarlyView.
We present a combined imaging platform that integrates beamline‐compatible fluorescence microscopy with scanning small‐angle X‐ray scattering to enable sequential multimodal investigations of hydrated cells under near‐native conditions. We apply our method to ordered cytoskeletal structures in different cell types and demonstrate the direct correlation
Mangalika Sinha, Boram Yu, Rita Mendes Da Silva, Ulrike Rölleke, Peter Luley, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Manfred Burghammer, Sarah Köster   +8 more
wiley   +1 more source

Scalable fabrication of an array-type fixed-target device for automated room temperature X-ray protein crystallography. [PDF]

Sci Rep
Saha S, Chen Y, Russi S, Marchany-Rivera D, Cohen A, Perry SL.   +5 more
europepmc   +1 more source

A versatile on‐axis visualization system for the macromolecular crystallography beamline BM07 at the ESRF

Journal of Synchrotron Radiation, EarlyView.
A compact on‐axis microscope installed on the endstation of the macromolecular crystallography beamline BM07 at the ESRF is described. The system combines dual‐magnification on‐axis sample visualization with on‐axis laser injection and fluorescence measurements in back‐scattering geometry.
Alexandre Appolaire, Philippe Jacquet, Lucas Petit, Eric Mathieu, Eric Girard, Sylvain Engilberge, Antoine Royant   +6 more
wiley   +1 more source

The current status and future prospects of the Synchrotron Radiation Protein Crystallography Core Facility at NSRRC: a focus on the TPS 05A, TPS 07A and TLS 15A1 beamlines. [PDF]

J Synchrotron Radiat
Chou CK, Tseng CC, Chiang CH, Chen YH, Liu YC, Huang CY, Chao CH, Huang CH.   +7 more
europepmc   +1 more source

Proteins and Crystallography [PDF]

Nature, 1963
openaire   +1 more source

Mapping Allergen B‐ and T‐Cell Epitopes: Technological Advances and Their Role in Precision Allergy Therapy

Allergy, EarlyView.
ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche, Josefine Corneliussen, Kristoffer H. Johansen, Alexandre Ruiz‐Carrasco, Caroline Paulsen, Yuchen Li, Carolina Barra, Sandhya Bangaru, Monica L. Fernández‐Quintero, Ewa Bartko, Lars Blom, Esperanza Rivera‐de‐Torre   +11 more
wiley   +1 more source