Results 201 to 210 of about 4,121,048 (281)

Polyoxometalates: more than a phasing tool in protein crystallography. [PDF]

ChemTexts, 2018
Bijelic A, Rompel A.
europepmc   +1 more source

Probing the role of the conserved residue Glu166 in a class A β-lactamase using neutron and X-ray protein crystallography. [PDF]

Acta Crystallogr D Struct Biol, 2020
Langan PS, Sullivan B, Weiss KL, Coates L.   +3 more
europepmc   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

Radiation damage in protein crystallography at X-ray free-electron lasers. [PDF]

Acta Crystallogr D Struct Biol, 2019
Nass K.
europepmc   +1 more source

Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. [PDF]

Biochemistry, 2020
Matthews MM, McArthur JB, Li Y, Yu H, Chen X, Fisher AJ.   +5 more
europepmc   +1 more source

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

The FEBS Journal, EarlyView.
Athe_2052 is an ABC transporter substrate‐binding protein that recognizes xyloglucan heptasaccharide (XXXG), a soluble breakdown product of plant xyloglucan. The crystal structure of Athe_2052, together with binding assays and computational modeling, shows how XXXG is recognized by this sugar transporter.
Hansen Tjo, Virginia Jiang, Philip D. Jeffrey, Angela Zhu, A. James Link, Jerelle A. Joseph, Jonathan M. Conway   +6 more
wiley   +1 more source

Rigid-body motion is the main source of diffuse scattering in protein crystallography. [PDF]

IUCrJ, 2019
de Klijn T, Schreurs AMM, Kroon-Batenburg LMJ.   +2 more
europepmc   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Ligand complex structures in protein crystallography. [PDF]

Acta Crystallogr D Struct Biol, 2017
Debreczeni JÉ, Emsley P.
europepmc   +1 more source

Ion binding sites and intermediate domain closure induced by D‐serine in the GluD1 ligand‐binding domain

The FEBS Journal, EarlyView.
GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen, Emma Grosvald Pedersen, Dilip Narayanan, Karla A. Frydenvang, Jette Sandholm Kastrup   +4 more
wiley   +1 more source