Results 211 to 220 of about 4,121,048 (281)
The FEBS Journal, EarlyView.We present the first crystal structures of human NIF3, revealing a dynamic, hexameric ring with a central cavity regulated by flexible insertion domains. Crucially, human NIF3 features a mononuclear zinc‐binding site, marking a distinct evolutionary departure from the dinuclear centers of bacterial homologs.
Elżbieta Wątor‐Wilk +6 more
wiley +1 more source
The FEBS Journal, EarlyView.Shown is a typical detail of a high‐resolution crystal structure (PDB ID 1B5E, chain A) showing the nearness of a phenylalanine residue, Phe24, and a lysine residue, Lys32, that are not engaged in the proposed cation–π interaction. The study statistically examines charged residues near phenylalanine's aromatic ring, supported by quantum chemical ...
Hessel Poelman +6 more
wiley +1 more source
Dimerization of human PARP15 is required for NAD+ binding and automodification
The FEBS Journal, EarlyView.This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen +9 more
wiley +1 more source
Catalysis and allostery in bacterial ATP phosphoribosyltransferases
The FEBS Journal, EarlyView.ATP phosphoribosyltransferase (ATPPRT) catalyses the first reaction of L‐histidine biosynthesis. L‐Histidine allosterically inhibits ATPPRT to regulate this energy‐intensive pathway in histidine‐synthesising organisms, such as bacteria, archaea and plants.
Lillian G. Bates, Rafael G. da Silva
wiley +1 more source
The FEBS Journal, EarlyView.Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta +1 more
wiley +1 more source
The FEBS Journal, EarlyView.Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal +18 more
wiley +1 more source
Journal of Microscopy, EarlyView.Abstract Since its introduction 40 years ago, atomic force microscopy (AFM) has transformed nanoscale imaging across the physical and life sciences. In biology, AFM has provided unprecedented insights into nanoscale biomolecular organisation under near‐physiological conditions, revealing structures and interactions inaccessible to many conventional ...
Yueqi Wang +5 more
wiley +1 more source
AI foundation models in plant biology
New Phytologist, EarlyView.Foundation models decode genomes, engineer proteins, phenotype crops, and drive AI agents across plant biology. This figure was created in BioRender (BioRender.com/xcmmkel). Summary Rapid technological progress has enabled plant biologists to accumulate unprecedented volumes of multi‐scale, multi‐modal data, yet this abundance of data has intensified ...
Haopeng Yu
wiley +1 more source
School Science and Mathematics, EarlyView.ABSTRACT This qualitative case study examined how the Center for Science and the Schools (CSATS), a university‐based intermediary organization, sustained partnerships between STEM researchers and K‐12 educators over 20 years (2004–2024). Data were collected through surveys of 21 STEM research faculty across 16 disciplines, 11 current and former CSATS ...
Kathleen M. Hill +5 more
wiley +1 more source
Crystal Dehydration in Membrane Protein Crystallography. [PDF]
Adv Exp Med Biol, 2016 Sanchez-Weatherby J, Moraes I.
europepmc +1 more source