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Protein crystallography microdiffraction
Current Opinion in Structural Biology, 2005Protein microdiffraction using monochromatic beams is becoming a routine tool at third-generation synchrotron radiation sources. Beam sizes have reached the scale of about 5 microm, with illuminated crystal volumes of approximately 500 microm3, as shown for the case of bovine rhodopsin, which was refined to a resolution of 2.6 A.
Christian, Riekel +2 more
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Protein crystallography in Australia
Australian and New Zealand Journal of Medicine, 1995Abstract:Protein crystallography is the study of the three‐dimensional shapes of proteins at near atomic resolution. The field has provided a tremendous insight into the workings of numerous biological processes over the last few decades. The field is presently undergoing a massive worldwide expansion, not only in academic laboratories but also in the ...
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Phase Retrieval in Protein Crystallography
Acta Crystallographica Section A: Foundations and Advances, 2012Solution of the phase problem is central to crystallographic structure determination. An oversampling method is proposed, based on the hybrid input-output algorithm (HIO) [Fienup (1982). Appl. Opt. 21, 2758-2769], to retrieve the phases of reflections in crystallography.
Yuhui Dong, Dong Y -H
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Computational Tools in Protein Crystallography
2010Protein crystallography emerged in the early 1970s and is, to this day, one of the most powerful techniques for the analysis of enzyme mechanisms and macromolecular interactions at the atomic level. It is also an extremely powerful tool for drug design.
Jain, Deepti, Lamour, Valerie
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Advances in kinetic protein crystallography
Current Opinion in Structural Biology, 2005Many proteins function in the crystalline state, making crystallography a tool that can address mechanism, as well as structure. By initiating biological turnover in the crystal, transient structural species form, which may be filmed by Laue diffraction or captured by freeze-trapping methods.
Dominique, Bourgeois, Antoine, Royant
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Hands-off protein crystallography
Nature Methods, 2006A new microfluidic protein crystallization device allows users to screen 'kinetic' rather than chemical conditions to grow high-quality crystals that can be diffracted in situ.
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Radiation damage in protein crystallography
Journal of Molecular Biology, 1976Abstract A general model is derived to describe the rate of radiation damage in protein crystals. This model and some of its special cases are tested against the Blake and Phillips data on X-irradiation effects in myoglobin crystals. The results point to a sequential process of damage and suggest an improved method for correcting diffraction data for
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Protein Crystallography and Drug Design
1987Safe and reliable drugs belong to the most impressive scientific achievements of mankind. One would only wish that there were more drugs such as penicillin which allows recovery from serious and painful bacterial infections in a matter of days, if not hours.
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Protein crystallography for all
Proteins: Structure, Function, and Bioinformatics, 1994openaire +2 more sources