Results 301 to 310 of about 1,734,521 (378)

Advanced Micro‐OLED Integration on Thin and Flexible Polymer Neural Probes for Targeted Optogenetic Stimulation

Advanced Functional Materials, EarlyView.
This paper introduces a flexible neural probe with integrated micro‐OLEDs on a flexible substrate for the first time, featuring 8 micro‐OLEDs and recording electrodes for optogenetics. It uses advanced encapsulation and an IAI anode for durability, emitting 470 nm light for ChR2 activation, enabling high‐resolution, minimally invasive stimulation ...
Somin Lee, Mi Kyung Kim, Seonil Kwon, Jia Chee Leong, Byeongju Noh, Junhee Sim, Eun Gyo Jeong, Hyunjoo J. Lee, Kyung Cheol Choi   +8 more
wiley   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation. [PDF]

ChemMedChem
Yim J, Park J, Kim G, Lee HH, Chung JS, Jo A, Koh M, Park J.   +7 more
europepmc   +1 more source

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

Advanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou, Lauren Brown, Christopher M. Madl   +2 more
wiley   +1 more source

Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation. [PDF]

Pharmaceutics
Vrbnjak K, Sewduth RN.
europepmc   +1 more source

Cell Membrane Vesicle Camouflaged Artificial Cells

Advanced Functional Materials, EarlyView.
Artificial cells camouflaged with a cell membrane vesicle coating are able to assemble into synthetic aggregates that exhibit rudimentary communication capabilities. Additionally, when these artificial cells are equipped with antioxidant capabilities, they are able to protect the intracellular homeostasis in HepG2 cells present in semi‐synthetic ...
Paula De Dios Andres, Stefan Pendlmayr, Noga Gal, Cathrine Abild Meyer, Cecilie Ryberg, Olav Vestrheim, Noel Angelo Kalacas, Fatih Demir, Markus M. Rinschen, Karsten Haupt, Rajeshwar Prosad Mookerjee, Brigitte Städler   +11 more
wiley   +1 more source

Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy. [PDF]

Autophagy
Leytens A, Benítez-Fernández R, Jiménez-García C, Roubaty C, Stumpe M, Boya P, Dengjel J.   +6 more
europepmc   +1 more source

A Strong and Water‐Retaining Biomass Adhesive Inspired by Tofu

Advanced Functional Materials, EarlyView.
Drawing inspiration from the formation mechanism of the traditional food tofu, a strong and water‐retaining adhesive is designed using the soybean meal (SM) oxidized by glucose oxidase (GOx) and calcium sulfate oligomer (CSO). This design strategy effectively addresses the conflicting requirements of water‐resistant bonding strength and water retention
Jiawei Shao, Qiumei Jing, Xinyi Li, Muhammad Wakil Shahzad, Shuaicheng Jiang, Xuehua Zhang, Shengbo Ge, Ben Bin Xu, Jianzhang Li   +8 more
wiley   +1 more source

Selective protein degradation through chaperone‑mediated autophagy: Implications for cellular homeostasis and disease (Review). [PDF]

Mol Med Rep
Huang J, Wang J.
europepmc   +1 more source