Results 301 to 310 of about 1,856,978 (353)
Some of the next articles are maybe not open access.
Eukaryotic protein degradation
Current Opinion in Cell Biology, 1990Early studies of intracellular protein degradation revealed several properties common to all types of eukaryotic cells. Cellular proteins are continuously turning over and measurements of the fate of individual proteins have shown them to have widely differing half-lives (ranging from a few minutes to many days).
openaire +2 more sources
Lysosomes and protein degradation
Biochemical Society Transactions, 1977Considerable evidence from studies with group-specific proteinase inhibitors, in particular pepstatin, the aspartic proteinase inhibitor, implicates lysosomes in turnover of endogenous cellular proteins. Recent experiments using a new group-specific inhibitor of thiol (cysteine) proteinases, Z-Phe-Ala-diazomethyl ketone, are described.
openaire +3 more sources
RAT MYOCARDIAL PROTEIN DEGRADATION
Clinical and Experimental Pharmacology and Physiology, 1981SUMMARY1. Myocardial protein degradation rates were determined by following tyrosine release from rat isolated left hemi‐atria in vitro.2. After two 20 min preincubations the rate of tyrosine release from hemi‐atria was constant for 4 h.3. Skeletal muscle protein degradation was determined by following tyrosine release from rat isolated hemi‐diaphragm (
J H, Steer, B E, Hopkins
openaire +2 more sources
Monomeric Targeted Protein Degraders
Journal of Medicinal Chemistry, 2020The discovery and development of targeted protein degraders have become important areas of research in the field of medicinal chemistry. Inducing degradation of a target protein presents several advantages relative to simple inhibition including a potential for extended duration of action and more profound pharmacology.
Emily J. Hanan +5 more
openaire +2 more sources
Protein degradation in signaling
Current Opinion in Plant Biology, 2000Recent studies have linked proteolysis by the ubiquitin/proteasome pathway to a variety of signaling pathways in higher plants. These links were uncovered by characterization of mutants altered in signaling or by targeted disruption of components of the proteolytic pathway. Significant advances have recently revealed connections between proteolysis and
J, Callis, R D, Vierstra
openaire +2 more sources
Monitoring protein degradation
2002Publisher Summary Protein degradation processes can be divided in two categories: bulk degradation and selective degradation of specific proteins. Individual protein species can differ in stability by several orders of magnitude. Constitutive fast turnover of a protein allows the rapid modulation of its concentration in response to changes in its ...
openaire +2 more sources
Experimental Gerontology, 2005
Continuous turnover of intracellular proteins is essential for the maintenance of cellular homeostasis and for the regulation of multiple cellular functions. The first reports showing a decrease in total rates of protein degradation with age are dated more than 50 years ago, when the major players in protein degradation where still to be discovered ...
Marta, Martinez-Vicente +2 more
openaire +2 more sources
Continuous turnover of intracellular proteins is essential for the maintenance of cellular homeostasis and for the regulation of multiple cellular functions. The first reports showing a decrease in total rates of protein degradation with age are dated more than 50 years ago, when the major players in protein degradation where still to be discovered ...
Marta, Martinez-Vicente +2 more
openaire +2 more sources
Targeted protein degradation mechanisms
Drug Discovery Today: Technologies, 2019Targeted protein degradation mediated by small molecule degraders represents an exciting new therapeutic opportunity to eliminate disease-causing proteins. These molecules recruit E3 ubiquitin ligases to the protein of interest and mediate its ubiquitination and subsequent proteolysis by the proteasome.
Yi, Zhang +3 more
openaire +2 more sources
SnapShot: Targeted protein degradation
CellTargeted protein degradation strategies leverage endogenous cellular degradation machinery to selectively eliminate a protein of interest. Emerging technologies are opening avenues in drug discovery and functional characterization of intracellular, membrane, and extracellular proteins. To view this SnapShot, open or download the PDF.
Yu, Ding, Boxun, Lu
openaire +2 more sources
Targeted protein degradation and the enzymology of degraders
Current Opinion in Chemical Biology, 2018Targeted protein degradation is an emerging strategy for drug discovery that employs small molecules to catalyze the ubiquitination of target proteins, ultimately causing their degradation by the proteasome. Current degrader designs employ hetero-bivalent molecules to recruit E3 ubiquitin ligases such as VHL, Cereblon, and the IAPs to the target ...
Stewart L, Fisher, Andrew J, Phillips
openaire +2 more sources