Results 311 to 320 of about 1,856,978 (353)
Some of the next articles are maybe not open access.
Molecular Machines for Protein Degradation
ChemBioChem, 2005AbstractOne of the most precisely regulated processes in living cells is intracellular protein degradation. The main component of the degradation machinery is the 20S proteasome present in both eukaryotes and prokaryotes. In addition, there exist other proteasome‐related protein‐degradation machineries, like HslVU in eubacteria.
Groll, M. +4 more
openaire +3 more sources
Linkers for protein degradation
Nature Chemical Biology, 2018The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.
openaire +2 more sources
UBIQUITIN-DEPENDENT PROTEIN DEGRADATION
Annual Review of Genetics, 1996▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein modification by the polypeptide ubiquitin. These include key transitions in the cell cycle, class I antigen processing, signal transduction pathways, and receptor-mediated endocytosis.
openaire +2 more sources
Toxicologic Pathology
The so-called undruggable space is an exciting area of potential growth for drug development. Undruggable proteins are defined as those unable to be targeted via conventional small molecule drugs. New modalities are being developed to potentially target these proteins.
Kiran Palyada +7 more
openaire +2 more sources
The so-called undruggable space is an exciting area of potential growth for drug development. Undruggable proteins are defined as those unable to be targeted via conventional small molecule drugs. New modalities are being developed to potentially target these proteins.
Kiran Palyada +7 more
openaire +2 more sources
Protein degradation in bacteria
Archives of Biochemistry and Biophysics, 1953Summary 1. Under aerobic conditions which permit growth of Escherichia coli , the rate of protein degradation, as measured by loss of labeled arginine from the acid-insoluble fraction of the culture, is at least 8 ± 2% per 30 hr. 2. When such cells grown in a synthetic medium are transferred to a secondary medium containing a complete amino ...
openaire +2 more sources
Archives of Biochemistry and Biophysics, 1953
Abstract Rate equations for a degrading system based on a simple step mechanism are considered. The initial attack is assumed to occur at random. It is followed by a further random depolymerization of the intermediate fragments but, in general, at a different rate.
openaire +2 more sources
Abstract Rate equations for a degrading system based on a simple step mechanism are considered. The initial attack is assumed to occur at random. It is followed by a further random depolymerization of the intermediate fragments but, in general, at a different rate.
openaire +2 more sources
EXTRALYSOSOMAL PROTEIN DEGRADATION
Annual Review of Biochemistry, 1986PONTREMOLI, SANDRO, MELLONI, EDON
openaire +3 more sources
Nature Chemical Biology
In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
openaire +3 more sources
In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
openaire +3 more sources
The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly