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Catching proteins for degradation
Science, 2023A ubiquitin-independent pathway targets nuclear proteins to the ...
Charlotte M, Schilling +1 more
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Protein degradation in signaling
Current Opinion in Plant Biology, 2000Recent studies have linked proteolysis by the ubiquitin/proteasome pathway to a variety of signaling pathways in higher plants. These links were uncovered by characterization of mutants altered in signaling or by targeted disruption of components of the proteolytic pathway. Significant advances have recently revealed connections between proteolysis and
Judy Callis, Richard D. Vierstra
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Experimental Gerontology, 2005
Continuous turnover of intracellular proteins is essential for the maintenance of cellular homeostasis and for the regulation of multiple cellular functions. The first reports showing a decrease in total rates of protein degradation with age are dated more than 50 years ago, when the major players in protein degradation where still to be discovered ...
Guy Sovak +2 more
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Continuous turnover of intracellular proteins is essential for the maintenance of cellular homeostasis and for the regulation of multiple cellular functions. The first reports showing a decrease in total rates of protein degradation with age are dated more than 50 years ago, when the major players in protein degradation where still to be discovered ...
Guy Sovak +2 more
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Regulated protein degradation [PDF]
Trends in Biochemical Sciences, 2005 1 Rheinberger, H-J. (2004) A history of protein biosynthesis andribosome research. In Protein Synthesis and Ribosome Structure(Nierhaus, K.H. and Wilson, D.N., eds), pp. 1–51, Wiley-VCH Verlag2 Green, A.A. et al. (1954) The structure of haemoglobin. IV. Signdetermination by the isomorphous replacement method. Proc. Roy.Soc. A225, 287–3073 Ban, N. et al.
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Regulated protein degradation in mitochondria [PDF]
Experientia, 1996 Various adenosine triphosphate (ATP)-dependent proteases were identified within mitochondria which mediate selective mitochondrial protein degradation and fulfill crucial functions in mitochondrial biogenesis. The matrix-localized PIM1 protease, a homologue of the Escherichia coli Lon protease, is required for respiration and maintenance of ...
Langer, T., Neupert, W.
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Archives of Biochemistry and Biophysics, 1953
Abstract Rate equations for a degrading system based on a simple step mechanism are considered. The initial attack is assumed to occur at random. It is followed by a further random depolymerization of the intermediate fragments but, in general, at a different rate.
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Abstract Rate equations for a degrading system based on a simple step mechanism are considered. The initial attack is assumed to occur at random. It is followed by a further random depolymerization of the intermediate fragments but, in general, at a different rate.
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Current Opinion in Chemical Biology, 2005
The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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Ubiquitination and Degradation of Proteins
2011Modification by ubiquitin (Ub) and ubiquitin-like proteins (UbLs) is involved in the regulation of numerous cellular processes and has therefore become an important subject of research in various areas of biomedicine. The large number of components of the system (∼1,500), most of them being ligases (∼800) that recognize their target substrates ...
Aaron Ciechanover +1 more
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Linkers for protein degradation
Nature Chemical Biology, 2018The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.
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Eukaryotic protein degradation
Current Opinion in Cell Biology, 1990Early studies of intracellular protein degradation revealed several properties common to all types of eukaryotic cells. Cellular proteins are continuously turning over and measurements of the fate of individual proteins have shown them to have widely differing half-lives (ranging from a few minutes to many days).
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