Results 211 to 220 of about 2,066,004 (263)

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications. [PDF]

Sci Adv
Galindo G, Maejima D, DeRoo J, Burlingham SR, Fixen G, Morisaki T, Febvre HP, Hasbrook R, Zhao N, Ghosh S, Mayton EH, Snow CD, Geiss BJ, Ohkawa Y, Sato Y, Kimura H, Stasevich TJ.   +16 more
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The Role of AI-Driven De Novo Protein Design in the Exploration of the Protein Functional Universe. [PDF]

Biology (Basel)
Zhang G, Liu C, Lu J, Zhang S, Zhu L.
europepmc   +1 more source

Susana Vázquez Torres: the power of computational protein design. [PDF]

Bull World Health Organ
europepmc   +1 more source

Protein design accelerates the development and application of optogenetic tools. [PDF]

Comput Struct Biotechnol J
Zhu L, Wang Y, Wu X, Wu G, Zhang G, Liu C, Zhang S.   +6 more
europepmc   +1 more source

Publisher Correction: Multistate and functional protein design using RoseTTAFold sequence space diffusion. [PDF]

Nat Biotechnol
Lisanza SL, Gershon JM, Tipps SWK, Sims JN, Arnoldt L, Hendel SJ, Simma MK, Liu G, Yase M, Wu H, Tharp CD, Li X, Kang A, Brackenbrough E, Bera AK, Gerben S, Wittmann BJ, McShan AC, Baker D.   +18 more
europepmc   +1 more source

The Protein Design Archive (PDA): insights from 40 years of protein design

Chronowska M, Stam MJ, Woolfson DN, Di Costanzo LF, Wood CW.   +4 more
europepmc   +1 more source

Effective sequence-to-expression prediction for membrane proteins using machine learning and computational protein design

Shen Y, Underhill J, Mulholland AJ, Oyarzún DA, Curnow P.   +4 more
europepmc   +1 more source

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Protein Assembly by Design

Chemical Reviews, 2021
Proteins are nature's primary building blocks for the construction of sophisticated molecular machines and dynamic materials, ranging from protein complexes such as photosystem II and nitrogenase that drive biogeochemical cycles to cytoskeletal assemblies and muscle fibers for motion. Such natural systems have inspired extensive efforts in the rational
Jie Zhu, Nicole Avakyan, Albert Kakkis, Alexander M. Hoffnagle, Kenneth Han, Yiying Li, Zhiyin Zhang, Tae Su Choi, Youjeong Na, Chung-Jui Yu, F. Akif Tezcan   +10 more
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Designing cooperativity into the designed protein Top7

Proteins: Structure, Function, and Bioinformatics, 2013
ABSTRACTThe topology of the designed protein Top7 is not found in natural proteins. Top7 shows signatures of non‐cooperative folding in both experimental studies and computer simulations. In particular, molecular dynamics of coarse‐grained structure‐based models of Top7 show a well‐populated C‐terminal folding‐intermediate.
Shilpa, Yadahalli, Shachi, Gosavi
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Design and designability of protein-based assemblies

Current Opinion in Structural Biology, 2014
Design of protein-based assemblies is an exciting frontier in molecular engineering. It can be seen as an extension of the protein design problem, but with some added hurdles. In recent years, much of the focus in the field has been on patterning existing protein structural units (proteins, oligomers, or structural motifs) to design diverse assembly ...
Jian, Zhang, Fan, Zheng, Gevorg, Grigoryan   +2 more
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