Results 231 to 240 of about 2,066,004 (263)
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Designing Fluorinated Proteins
2016As methods to incorporate noncanonical amino acid residues into proteins have become more powerful, interest in their use to modify the physical and biological properties of proteins and enzymes has increased. This chapter discusses the use of highly fluorinated analogs of hydrophobic amino acids, for example, hexafluoroleucine, in protein design.
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Annual Review of Biochemistry, 2013
Diverse engineering strategies have been developed to create enzymes with novel catalytic activities. Among these, computational approaches hold particular promise. Enzymes have been computationally designed to promote several nonbiological reactions, including a Diels-Alder cycloaddition, proton transfer, multistep retroaldol transformations, and ...
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Diverse engineering strategies have been developed to create enzymes with novel catalytic activities. Among these, computational approaches hold particular promise. Enzymes have been computationally designed to promote several nonbiological reactions, including a Diels-Alder cycloaddition, proton transfer, multistep retroaldol transformations, and ...
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2022
Computational Protein Design has the potential to contribute to major advances in enzyme technology, vaccine design, receptor-ligand engineering, biomaterials, nanosensors, and synthetic biology. Although Protein Design is a challenging problem, proteins can be designed by experts in Protein Design, as well as by non-experts whose primary interests are
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Computational Protein Design has the potential to contribute to major advances in enzyme technology, vaccine design, receptor-ligand engineering, biomaterials, nanosensors, and synthetic biology. Although Protein Design is a challenging problem, proteins can be designed by experts in Protein Design, as well as by non-experts whose primary interests are
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Carbohydrates in peptide and protein design
Peptide Science, 2005AbstractMonosaccharides and amino acids are fundamental building blocks in the assembly of nature's polymers. They have different structural aspects and, to a significant extent, different functional groups. Oligomerization gives rise to oligosaccharides and peptides, respectively. While carbohydrates and peptides can be found conjoined in nature, e.g.,
Jensen, Knud J., Brask, Jesper
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Optimal Protein Design Procedure
Physical Review Letters, 1996We discuss a general method for protein design based on an analysis in sequence space of the Boltzmann weight for a given target structure. An efficient Monte Carlo code that explores sequence space (and, for each sequence, the space of compact and noncompact conformations) is implemented and tested in two models in two dimensions which are amenable to
SENO, FLAVIO +3 more
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Design of Peptides and Proteins
1988Publisher Summary This chapter focuses on contemporary approaches to the design of structurally defined peptides and proteins with special emphasis being given to the ways in which this approach has elucidated the structural basis for the function of a variety of natural molecules.
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Automatic Procedures for Protein Design
Combinatorial Chemistry & High Throughput Screening, 2001This review describes computational procedures for deriving the amino acid sequences that are compatible with a given protein backbone structure. Such procedures can be used to gain insight into the constraints imposed by the 3D structure of the protein sequence, or to design proteins that are likely to adopt a given backbone conformation.
Jaramillo, Alfonso +3 more
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Designing protein function – Macromolecular design
Journal of Structural Biology, 2014Höcker, B. ; https://orcid.org/0000-0002-8250-9462 +1 more
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De novo design of protein structure and function with RFdiffusion
Nature, 2023Joseph Watson +2 more
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De novo protein design by deep network hallucination
Nature, 2021Cameron M Chow, Alex Kang, David Baker
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