Results 241 to 250 of about 16,987,595 (305)

Stable de novo protein design via joint conformational landscape and sequence optimization. [PDF]

Nat Commun
Cho Y, Dauparas J, Tsuboyama K, Rocklin GJ, Ovchinnikov S.   +4 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design. [PDF]

Proc Natl Acad Sci U S A
Sevgen E, Moller J, Lange A, Parker J, Quigley S, Mayer J, Srivastava P, Gayatri S, Hosfield D, Dilks C, Buchanan C, Speltz T, Korshunova M, Livne M, Gill M, Ranganathan R, Costa AB, Ferguson AL.   +17 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Optimization of CEST MRI Reporter Protein Design Using Cation-Pi Networks. [PDF]

Chemistry
Korenchan DE, French EJ, Runco E, Dhakan CB, Yan J, Nakashima H, McMahon MT, Gilad AA, Farrar CT.   +8 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

SAGE-prot: scoring-assisted generative exploration for multi-objective protein design. [PDF]

Brief Bioinform
Lim H, Lee GH, Cho H, No KT.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Protein Design Meets Single-Molecule Detection: Towards Programmable Nanopore Sensors. [PDF]

Int J Mol Sci
Liu X, Xu C.
europepmc   +1 more source