Results 101 to 110 of about 3,418,558 (223)
Stability and Conformational Resilience of Protein Disulfide Isomerase
Biochemistry, 2019 Protein disulfide isomerase (PDI) is a redox-dependent protein with oxidoreductase and chaperone activities. It is a U-shaped protein with an abb'xa' structural organization in which the a and a' domains have CGHC active sites, the b and b' domains are involved with substrate binding, and x is a flexible linker. PDI exhibits substantial flexibility and
Jessica Guyette +3 more
openaire +3 more sources
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, Volume 2, Issue 3, Page 334-351, September 2026.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi +11 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
Formation of enzyme—substrate disulfide linkage during catalysis by protein disulfide isomerase [PDF]
, 1991 During the regeneration of native ribonuclease A (RNase) from the disulfide scrambled molecule by protein disulfide isomerase (PDI), the substrate forms a covalent intermediate with the enzyme through disulfide linkage(s).
Chao-Hong Hu +3 more
core +1 more source
Extracellular PDI in thrombosis and vascular injury
Thrombosis JournalProtein disulfide isomerase (PDI) catalyzes the reduction, oxidation, and isomerization of disulfide bonds. Although initially discovered as an endoplasmic reticulum (ER)-residing protein, PDI has been demonstrated to play critical roles on cell surfaces
Jinyu Wang +3 more
doaj +1 more source
MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source
Characterisation of cytosolic prion protein-mediated putative cytotoxicity in neuronal cell lines [PDF]
, 2007 Prion diseases are a complex group of fatal neurodegenerative disorders with a broad host spectrum, which are characterised by strong neuronal cell loss, spongiform vacuolation and astrocytic proliferation.
Mehlhase, Jana
core
Methods of measuring Protein Disulfide Isomerase activity: a critical overview
Frontiers in Chemistry, 2014 Protein disulfide isomerase is an essential redox chaperone from the endoplasmic reticulum (ER) and is responsible for correct disulfide bond formation in nascent proteins.
Monica Massako Watanabe +2 more
doaj +1 more source