Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 5, May 2026.We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
wiley +1 more source
Proapoptotic Activities of Protein Disulfide Isomerase (PDI) and PDIA3 Protein, a Role of the Bcl-2 Protein Bak [PDF]
, 2015 Guoping Zhao, Huayi Lü, Chi Li
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Molecular Nutrition &Food Research, Volume 70, Issue 10, 27 May 2026.This study characterized the sex‐dependent hepatic molecular mechanisms of action of dietary cocoa in the context of a high‐fat diet in a mouse model. These findings demonstrate the potential of dietary cocoa as a clinical intervention in managing obesity‐associated fatty liver diseases in both sexes.
Juhui Jin +5 more
wiley +1 more source
Structural and functional characterization of the oxidoreductase a-DsbA1 from wolbachia pipientis
, 2009 The α-proteobacterium Wolbachia pipientis is a highly successful intracellular endosymbiont of invertebrates that manipulates its host\u27s reproductive biology to facilitate its own maternal transmission. The fastidious nature of Wolbachia and the
Frei, Patrick +9 more
core +1 more source
Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene [PDF]
, 2020 Daniela Kajihara +9 more
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Protein Science, Volume 35, Issue 5, May 2026.Abstract The endoplasmic reticulum (ER) provides a specialized environment for the folding of secreted and membrane proteins, a process supported by many different chaperones. Among these chaperones, peptidyl‐prolyl cis/trans isomerases (PPIases) catalyze a rate‐limiting conformational step in protein folding, yet the principles governing isoform ...
Sarah C. DeVoe +7 more
wiley +1 more source
nDsbD: a redox interaction hub in the Escherichia coli periplasm [PDF]
, 2018 .: DsbD is a redox-active protein of the inner Escherichia coli membrane possessing an N-terminal (nDsbD) and a C-terminal (cDsbD) periplasmic domain. nDsbD interacts with four different redox proteins involved in the periplasmic disulfide isomerization ...
Capitani, G. +3 more
core
RETRACTED ARTICLE: Protein disulfide-isomerase A3 knockdown attenuates oxidized low-density lipoprotein-induced oxidative stress, inflammation and endothelial dysfunction in human umbilical vein endothelial cells by downregulating activating transcription factor 2 [PDF]
, 2022 Jing Jia +6 more
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Protein Science, Volume 35, Issue 5, May 2026.Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney +12 more
wiley +1 more source
Cloning, expression, purification and characterization of Leishmania tropica PDI-2 protein
Open Life Sciences, 2016 In Leishmania species, protein disulfide isomerase (PDI) is an essential enzyme that catalyzes thiol-disulfide interchange. The present work describes the isolation, cloning, sequencing and expression of the pdI-2 gene.
Ali Dina +3 more
doaj +1 more source