Results 131 to 140 of about 677,670 (306)
Generation of Photocaged Nanobodies for Intracellular Applications in an Animal Using Genetic Code Expansion and Computationally Guided Protein Engineering** [PDF]
, 2022 Jack M. O’Shea +5 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1
Signal Transduction and Targeted Therapy, 2023 Chunyun Sun +9 more
doaj +1 more source
Editor's Choice Protein engineering strategies to develop lectins by design. [PDF]
GlycobiologyHombu R, Beatty LE, Neelamegham S.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
BAGEL: Protein engineering via exploration of an energy landscape. [PDF]
PLoS Comput BiolLála J +2 more
europepmc +1 more source