Results 131 to 140 of about 1,281,585 (240)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Rational protein engineering using an omni-directional multipoint mutagenesis generation pipeline. [PDF]

iScience
Fan L, Wang H, Gao H, Ding Y, Zhao J, Luo H, Tu T, Wu N, Yao B, Guan F, Tian J, Huang H.   +11 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Benchmarking uncertainty quantification for protein engineering. [PDF]

PLoS Comput Biol
Greenman KP, Amini AP, Yang KK.
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Protein engineering in the deep learning era. [PDF]

mLife
Zhou B, Tan Y, Hu Y, Zheng L, Zhong B, Hong L.   +5 more
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering. [PDF]

Appl Microbiol Biotechnol
Patti S, De Rose SA, Isupov MN, Magrini Alunno I, Riva S, Ferrandi EE, Littlechild JA, Monti D.   +7 more
europepmc   +2 more sources

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana. [PDF]

Plant Biotechnol J
Harding MD, Sainsbury F.
europepmc   +1 more source

Protein engineering on subtilisin

International Journal of Biochemistry, 1991
openaire   +5 more sources