Results 141 to 150 of about 677,670 (306)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Best Practices for Machine Learning-Assisted Protein Engineering. [PDF]

J Chem Inf Model
Herrera-Rocha F, Medina-Ortiz D, Mauz F, Pleiss J, Davari MD.   +4 more
europepmc   +1 more source

Prediction and validation of nanowire proteins in Oleidesulfovibrio alaskensis G20 using machine learning and feature engineering

Dheeraj Raya, Vincent Peta, Alain Bertrand Bomgni, Shiva Aryal, D. Tuyen, Kalimuthu Jawaharraj, David R. Salem, Venkataramana Gadhamshetty, Saurabh Sudha Dhiman, Etienne Z. Gnimpiéba   +9 more
openalex   +1 more source

PEBank: A Comprehensive Database for Protein Engineering and Design [PDF]

, 2018
Connie Wang, Paul M. Chang, Marylouise Ary, Stephen L. Mayo, Barry D. Olafson   +4 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Protein Engineering and Drug Discovery: Importance, Methodologies, Challenges, and Prospects. [PDF]

Biomolecules
Mohammed A, Ibrahim NA, Basher NS.
europepmc   +1 more source

Genetic Engineering on <i>Bacillus thuringiensis</i> Insecticidal Proteins

, 1993
Keiko Nakamura, Yoshiyasu Yabusaki
openalex   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Structural and functional insights into internal domain replacement in SpCas9 for protein engineering. [PDF]

Sci Rep
Kim S, Won H, Bae J, Kim J, Choi J, Richar H, Kim YG, Choi HJ.   +7 more
europepmc   +1 more source

Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody [PDF]

, 2014
Céline Monnet, Sylvie Jorieux, Nathalie Souyris, Ouafa Zaki, Alexandra Jacquet, Nathalie Fournier, Fabien Crozet, Christophe de Romeuf, Khalil Bouayadi, Rémi Urbain, Christian K. Behrens, Philippe Mondon, Alexandre Fontayne   +12 more
openalex   +1 more source