Results 151 to 160 of about 677,670 (306)

protein engineering

, 2014
Citation: 'protein engineering' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.P04897 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Biophysics-based protein language models for protein engineering. [PDF]

Nat Methods
Gelman S, Johnson B, Freschlin CR, Sharma A, D'Costa S, Peters J, Gitter A, Romero PA.   +7 more
europepmc   +1 more source

Engineering genes for predictable protein expression

, 2012
Claes Gustafsson, Jeremy Minshull, Sridhar Govindarajan, Jon E. Ness, Alan Villalobos, Mark Welch   +5 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity. [PDF]

Nat Commun
Giddins M, Kratz AF, De Los Santos MB, Forget A, Tiwari R, Jang G, Blazejewski T, Qin C, Huang Y, Lao YH, Falconer T, Leong KW, Krogan N, Staller M, Wang H, Wei L, Chavez A.   +16 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Enzyme Engineering Database (EnzEngDB): a platform for sharing and interpreting sequence-function relationships across protein engineering campaigns. [PDF]

Nucleic Acids Res
Long Y, Abbasinejad F, Li FZ, Reinprecht P, Wittmann B, Kennemur JL, Carder H, Yang J, Lambert T, O'Meara R, Radtke L, Qin Z, Brinkmann-Chen S, Arnold F, Mora A.   +14 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Prodigy protein: Python package for zero-shot protein engineering using protein language models. [PDF]

BMC Bioinformatics
Massett M, Carr A.
europepmc   +1 more source