Results 261 to 270 of about 8,703,040 (401)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering. [PDF]

Nat Commun
Grubbe WS, Zhang B, Kauffman A, Byléhn F, Padoł K, Jung HG, Park SB, Priest JM, Özkan E, de Pablo JJ, Liang TJ, Zhao M, Mendoza JL.   +12 more
europepmc   +1 more source

Protein engineering and iterative multimodule optimization for vitamin B₆ production in Escherichia coli. [PDF]

Nat Commun, 2023
Liu L, Li J, Gai Y, Tian Z, Wang Y, Wang T, Liu P, Yuan Q, Ma H, Lee SY, Zhang D.   +10 more
europepmc   +1 more source

Protein engineering approach to the molten globule state of canime milk lysozyme.

, 1999
Takumi Koshiba, Hiroki Yamamoto, Yoshihiro Kobashigawa, Kunihiro Kuwajima, Katsutoshi Nitta   +4 more
openalex   +2 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors. [PDF]

Cancer Discov
Chang JF, Landmann JH, Chang TC, Selli ME, Tenzin Y, Warrington JM, Ritchey J, Hsu YS, Slade M, Gupta DK, DiPersio JF, Holehouse AS, Singh N.   +12 more
europepmc   +1 more source

Editorial: Biocatalysis and biotransformation guided by protein engineering. [PDF]

Front Bioeng Biotechnol, 2023
Li C, Yang K, Li H, Jia M, Guan L, Qin HM.   +5 more
europepmc   +1 more source

Enhanced Poly(ethylene terephthalate) Hydrolase Activity by Protein Engineering

Engineering, 2018
Yuan Ma, Mingdong Yao, Bing-Zhi Li, Ming-Zhu Ding, Bo He, Si Chen, Xiao Zhou, Yingjin Yuan   +7 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Critical Assessment of Protein Engineering (CAPE): A Student Challenge on the Cloud. [PDF]

ACS Synth Biol
Fu L, Gao Y, Chen Y, Wang Y, Fang X, Tian S, Dong H, Zhang Y, Chen Z, Wang Z, Hu S, Yi X, Si T.   +12 more
europepmc   +1 more source