Results 271 to 280 of about 8,703,040 (401)

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Biosynthesis of Halogenated Tryptophans for Protein Engineering Using Genetic Code Expansion. [PDF]

Chembiochem
Guo Y, Cheng L, Hu Y, Zhang M, Liu R, Wang Y, Jiang S, Xiao H.   +7 more
europepmc   +1 more source

Improved Stability and Manufacturability of Nucleocapsid Antigens for SARS-CoV2 Diagnostics through Protein Engineering. [PDF]

Biomolecules, 2023
Shukla E, Choudhury L, Rastogi S, Chawla A, Bhattacharya S, Kaushik U, Mittal M, Rathore AS, Pandey G.   +8 more
europepmc   +1 more source

Engineering Cowpea Mosaic Virus RNA-2 into a Vector to Express Heterologous Proteins in Plants

, 2000
Kodetham Gopinath, J. Wellink, Claudine Porta, Kathryn M. Taylor, George P. Lomonossoff, Ab van Kammen   +5 more
openalex   +1 more source

Construction of block-shuffled libraries of DNA for evolutionary protein engineering: Y-ligation-based block shuffling [PDF]

, 2002
Koichiro Kitamura, Yasunori Kinoshita, Shinsuke Narasaki, Naoto Nemoto, Yuzuru Husimi, Koichi Nishigaki   +5 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme. [PDF]

Toxins (Basel)
Dotsenko A, Sinelnikov I, Zorov I, Denisenko Y, Rozhkova A, Shcherbakova L.   +5 more
europepmc   +1 more source

Empowering gene delivery with protein engineering platforms. [PDF]

Gene Ther, 2023
Kizerwetter M, Pietz K, Tomasovic LM, Spangler JB.   +3 more
europepmc   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

A systematic analysis of regression models for protein engineering. [PDF]

PLoS Comput Biol
Michael R, Kæstel-Hansen J, Mørch Groth P, Bartels S, Salomon J, Tian P, Hatzakis NS, Boomsma W.   +7 more
europepmc   +1 more source