Results 301 to 310 of about 8,703,040 (401)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Editorial: Extremozymes: characteristics, structure, protein engineering and applications. [PDF]

Front Microbiol
Bhatt HB, Sani RK, Amoozegar MA, Singh SP.   +3 more
europepmc   +1 more source

Protein circuit engineering [PDF]

Nature Methods, 2018
openaire   +3 more sources

Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides

, 2001
Stefan Lutz
openalex   +2 more sources

Analysis of an ionic network within a protein oligomer and engineering towards higher thermostability [PDF]

, 2002
Bjørn Dalhus, Alexandra Bjørk, D. Mantzillas, Vincent G. H. Eijsink, Reidun Sirevåg   +4 more
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

PROSCA: an online platform for humanized scaffold mining facilitating rational protein engineering. [PDF]

Nucleic Acids Res
Wang X, Zhang Y, Li Z, Duan Z, Guo M, Wang Z, Zhu F, Xue W.   +7 more
europepmc   +1 more source

Recent patents in protein engineering [PDF]

, 2002

openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Structure Prediction and Protein Engineering Yield New Insights into Microcin J25 Precursor Recognition. [PDF]

ACS Chem Biol
Tan HN, Liu WQ, Ho J, Chen YJ, Shieh FJ, Liao HT, Wang SP, Hegemann JD, Chang CY, Chu J.   +9 more
europepmc   +1 more source