Results 51 to 60 of about 6,490,832 (265)

Origin and evolution of protein fold designs [PDF]

, 2012
The spatial arrangements of secondary structures in proteins, irrespective of their connectivity, depict the overall shape and organization of protein domains. These features have been used in the CATH and SCOP classifications to hierarchically partition
Bukhari, Syed
core  

Evolution of prokaryotic SPFH proteins. [PDF]

, 2009
BACKGROUND: The SPFH protein superfamily is a diverse family of proteins whose eukaryotic members are involved in the scaffolding of detergent-resistant microdomains. Recently the origin of the SPFH proteins has been questioned.
Reuter Alexander, Markus Hinderhofer, Möller, Heiko M., Möller Heiko M, Hinderhofer Markus, Hinderhofer, Markus, Heiko M Möller, Walker, Christina A, Walker Christina A, Christina A Walker, Stuermer, Claudia AO, Friemel, Anke, Möller, Heiko M, Claudia AO Stuermer, Walker, Christina A., Alexander Reuter, Friemel Anke, Reuter, Alexander, Anke Friemel, Claudia AO Sturmer, Stuermer Claudia AO, Stürmer, Claudia   +21 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Evolution signatures in genome network properties [PDF]

, 2011
Genomes maybe organized as networks where protein-protein association plays the role of network links. The resulting networks are far from being random and their topological properties are a consequence of the underlying mechanisms for genome evolution ...
Rodrigo Dalmolin, Mauro Castro, Ricardo Ferreira, José Luiz Rybarczyk-Filho, Rita de Almeida, Jose Claudio Moreira, Leonardo Brunnet   +6 more
core  

A script to highlight hydrophobicity and charge on protein surfaces [PDF]

, 2015
The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo, Stefan G. D. Rüdiger, Dominique Hagemans, Cellular Protein Chemistry, Ianthe A. E. M. van Belzen, Ianthe A.E.M. van Belzen, van Belzen, Ianthe A E M, Sub Cellular Protein Chemistry, Morán Luengo, Tania, Rüdiger, Stefan G D, Tania Morán Luengo, Dominique eHagemans, Hagemans, Dominique   +12 more
core   +2 more sources

Protein folding and the robustness of cells

, 2007
The intricate intracellular infrastructure of all known life forms is based on proteins. The folded shape of a protein determines both the protein’s function and the set of molecules it will bind to.
Zauner, Klaus-Peter, Tan, G. J. Shawn, Revilla, Ferran D.   +2 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evolution of Specificity in Protein-Protein Interactions [PDF]

Biophysical Journal, 2014
Hub proteins are proteins that maintain promiscuous molecular recognition. Because they are reported to play essential roles in cellular control, there has been a special interest in the study of their structural and functional properties, yet the mechanisms by which they evolve to maintain functional interactions are poorly understood.
Peleg, Orit, Choi, Jeong-Mo, Shakhnovich, Eugene I.   +2 more
openaire   +2 more sources

T2prhd: a tool to study the patterns of repeat evolution [PDF]

, 2008
BACKGROUND: The models developed to characterize the evolution of multigene families (such as the birth-and-death and the concerted models) have also been applied on the level of sequence repeats inside a gene/protein.
Andó István, István Andó, Pénzes, Zsolt, Andó, István, Sipos Botond, Botond Sipos, Zsolt Pénzes, Somogyi Kálmán, Somogyi, Kálmán, Sipos, Botond, Kálmán Somogyi, Pénzes Zsolt   +11 more
core   +1 more source