Results 111 to 120 of about 6,813,928 (408)
Diffusive Dynamics of the Reaction Coordinate for Protein Folding Funnels
, 1996 The quantitative description of model protein folding kinetics using a diffusive collective reaction coordinate is examined. Direct folding kinetics, diffusional coefficients and free energy profiles are determined from Monte Carlo simulations of a 27 ...
Onuchic, J. N. +2 more
core +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Scientific ReportsEvidence suggests that beta-amyloid (Aβ)-induced phosphorylation/aggregation of tau protein plays a critical role in the degeneration of neurons and development of Alzheimer’s disease (AD), the most common cause of dementia affecting the elderly ...
Pallabi Sil Paul +9 more
doaj +1 more source
Nature Communications, 2023 Recent breakthroughs in highly accurate protein structure prediction using deep neural networks have made considerable progress in solving the structure prediction component of the ‘protein folding problem’. However, predicting detailed mechanisms of how
Koji Ooka, Munehito Arai
doaj +1 more source
Chemistry & Biology, 2000 Various genome projects are identifying thousands of new protein sequences every year, which has led to an expanded interest in protein folding. There are two parts to the protein folding problem: the first is predicting the three-dimensional structure of a protein from its amino-acid sequence; and the second — the focus of this Web alert — is to ...
openaire +2 more sources
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Static and dynamic characteristics of protein contact networks [PDF]
, 2010 The principles underlying protein folding remains one of Nature's puzzles with important practical consequences for Life. An approach that has gathered momentum since the late 1990's, looks at protein hetero-polymers and their folding process through the lens of complex network analysis. Consequently, there is now a body of empirical studies describing
arxiv +1 more source
On the entropy of protein folding [PDF]
Protein Science, 1996 AbstractThe failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.
Peter L. Privalov, George I. Makhatadze
openaire +3 more sources
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Protein Folding and Mechanisms of Proteostasis
International Journal of Molecular Sciences, 2015 Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious
José Fernando Díaz-Villanueva +2 more
semanticscholar +1 more source