Results 121 to 130 of about 6,845,089 (390)
Folding and association of proteins
Progress in Biophysics and Molecular Biology, 1982 The acquisition of the native three-dimensional structure of proteins consists of sequential folding reactions with well-populated and well-defined structural intermediates. For small proteins successive stages in the folding have been resolved kinetically; these suggest that H-bonded elements of secondary structure are formed first, followed by ...
openaire +4 more sources
Native geometry and the dynamics of protein folding
, 2004 In this paper we investigate the role of native geometry on the kinetics of protein folding based on simple lattice models and Monte Carlo simulations.
Abkevich +28 more
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Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Does a Simple Lattice Protein Exhibit Self-Organized Criticality? [PDF]
, 2015 There are many unanswered questions when it comes to protein folding. These questions are interesting because the tertiary structure of proteins determines its functionality in living organisms.
Bajracharya, Arun +2 more
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Glassy Dynamics of Protein Folding
, 1999 A coarse grained model of a random polypeptide chain, with only discrete torsional degrees of freedom and Hookean springs connecting pairs of hydrophobic residues is shown to display stretched exponential relaxation under Metropolis dynamics at low ...
Ayşe Erzan +17 more
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Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation.
Chemical Reviews, 2018 Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less specific electrostatic interactions, impart important properties to proteins.
Huan‐Xiang Zhou, Xiaodong Pang
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Protein folding, protein structure and the origin of life: Theoretical methods and solutions of dynamical problems [PDF]
Theoretical methods and solutions of the dynamics of protein folding, protein aggregation, protein structure, and the origin of life are discussed. The elements of a dynamic model representing the initial stages of protein folding are presented.
Weaver, D. L.
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Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein. [PDF]
, 2014 Protein-protein interactions are at the heart of regulatory and signaling processes in the cell. In many interactions, one or both proteins are disordered before association.
core +1 more source
, 2007 Local minima and the saddle points separating them in the energy landscape are known to dominate the dynamics of biopolymer folding. Here we introduce a notion of a "folding funnel" that is concisely defined in terms of energy minima and saddle points ...
Becker +21 more
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