Results 141 to 150 of about 6,813,928 (408)
Concepts in protein folding [PDF]
FEBS Letters, 1992 Certain concepts and misconceptions in the field of protein folding are discussed from the viewpoint of a theoretical physicist. It is argued that there can be no protein folding code and that perceived correlations between sequence or composition and three‐dimensional structure are more likely to be an artefact of a limited database than a real result.
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Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
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Pathogens, 2018 PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as ...
Holger Wille, Jesús R. Requena
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Reading the three-dimensional structure of a protein from its amino acid sequence
, 2000 While all the information required for the folding of a protein is contained in its amino acid sequence, one has not yet learnt how to extract this information so as to predict the detailed, biological active, three-dimensional structure of a protein ...
Broglia, R. A., Tiana, G.
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Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
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Folding initiation sites and protein folding.
Acta Biochimica Polonica, 1999 The paper discusses the role of local structural preferences of protein segments in the folding of proteins. First a short overview of the local, secondary structures detected in peptides, protein fragments, denatured proteins and early folding intermediates is given.
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Protein folding: Prolyl isomerases join the fold [PDF]
Current Biology, 1995 Cyclophilins have prolyl isomerase activity, but evidence for their suggested role in protein folding in cells has been scarce; now they have been found to accelerate the folding of mitochondrial precursor proteins.
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Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
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Principle of Superposition in Protein-Folding [PDF]
arXiv, 2009 We propose a principle of superposition to describe protein-folding nuclei and explain an evolutional conservation of a field pattern specifying native-state structure.
arxiv
Intramolecular Folding of Proteins by Keto-Enol Interchange [PDF]
, 1937 W. T. ASTBURY, Dorothy Wrinch
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