Results 211 to 220 of about 6,771,465 (361)

From intrinsically disordered protein to context-dependent folding: The α-synuclein tetramer is teased out of hiding [PDF]

, 2015
Thomas C. Pochapsky
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

DR5 Disulfide Bonding Functions as a Sensor and Effector of Protein Folding Stress. [PDF]

Mol Cancer Res
Law ME, Dulloo ZM, Eggleston SR, Takacs GP, Alexandrow GM, Lee YI, Wang M, Hardy B, Su H, Forsyth B, Das P, Datta PK, Chiang CW, Sharma A, Kanumuri SRR, Guryanova OA, Harrison JK, Tirosh B, Castellano RK, Law BK.   +19 more
europepmc   +1 more source

Managing the protein folding demands in the endoplasmic reticulum of plants.

New Phytologist, 2016
Jian-Xiang Liu, S. Howell
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Endoplasmic reticulum oxidoreductin 1α as a potential therapeutic target in diseases: from oxidative protein folding to pathophysiological mechanisms. [PDF]

Front Pharmacol
He F, Ge X, Liu X.
europepmc   +1 more source

Protein Synthesis and Folding

, 2016

openalex   +1 more source

Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation.

Chemical Reviews, 2018
Huan‐Xiang Zhou, Xiaodong Pang
semanticscholar   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Dynamics in unfolded polypeptide chains as model for elementary steps in protein folding [PDF]

, 2004
Florian Krieger
openalex   +1 more source