Results 211 to 220 of about 3,672,982 (262)
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Quarterly Reviews of Biophysics, 1977
This review describes recent advances in studies on the stabilities of the three-dimensional structures of proteins and on the processes leading to the formation of these structures. The term ‘protein folding’ will be used here to denote the process of the conversion of an open polypeptide chain into the unique three-dimensional conformation of the ...
G, Némethy, H A, Scheraga
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This review describes recent advances in studies on the stabilities of the three-dimensional structures of proteins and on the processes leading to the formation of these structures. The term ‘protein folding’ will be used here to denote the process of the conversion of an open polypeptide chain into the unique three-dimensional conformation of the ...
G, Némethy, H A, Scheraga
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Annual Review of Biochemistry, 1981
After some general remarks on protein structure, there follows a discussion on primary, secondary, and tertiary organization. The account of primary structure includes a discussion of the conformation of disulfide bonds. Types of helices, sheets, and turns are described in the section on secondary structure, followed by a discussion of super-secondary ...
M G, Rossmann, P, Argos
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After some general remarks on protein structure, there follows a discussion on primary, secondary, and tertiary organization. The account of primary structure includes a discussion of the conformation of disulfide bonds. Types of helices, sheets, and turns are described in the section on secondary structure, followed by a discussion of super-secondary ...
M G, Rossmann, P, Argos
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The Hsp70–Hsp90 Chaperone Cascade in Protein Folding [PDF]
Trends in Cell Biology, 2019 Conserved families of molecular chaperones assist protein folding in the cell. Here we review the conceptual advances on three major folding routes: (i) spontaneous, chaperone-independent folding; (ii) folding assisted by repetitive Hsp70 cycles; and ...
Tania Morán Luengo +2 more
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On the Complexity of Protein Folding
Journal of Computational Biology, 1998We show that the protein folding problem in the two-dimensional H-P model is NP-complete.
CRESCENZI, PIERLUIGI +4 more
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How Fast-Folding Proteins Fold
Science, 2011Millisecond-scale molecular dynamics simulations of 12 proteins reveal a set of common principles for protein folding.
Kresten, Lindorff-Larsen +3 more
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Protein structures, folds and fold spaces
Journal of Physics: Condensed Matter, 2009There has been considerable progress towards the goal of understanding the space of possible tertiary structures adopted by proteins. Despite a greatly increased rate of structure determination and a deliberate strategy of sequencing proteins expected to be very different from those already known, it is now rare to see a genuinely new fold, leading to ...
Michael I, Sadowski, William R, Taylor
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2010
The existing experimental data on protein folding is briefly reviewed. It is argued that the optimal fit is within a multi-funnel shaped free energy landscape and a kinetic mechanism for folding. The possibility that the transient forces responsible for such a kinetic mechanism come from vibrational excited states (the VES hypothesis) is introduced ...
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The existing experimental data on protein folding is briefly reviewed. It is argued that the optimal fit is within a multi-funnel shaped free energy landscape and a kinetic mechanism for folding. The possibility that the transient forces responsible for such a kinetic mechanism come from vibrational excited states (the VES hypothesis) is introduced ...
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Annual Review of Biochemistry, 1997
The last stage of protein folding, the “endgame,” involves the ordering of amino acid side-chains into a well defined and closely packed configuration. We review a number of topics related to this process. We first describe how the observed packing in protein crystal structures is measured.
M, Levitt +4 more
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The last stage of protein folding, the “endgame,” involves the ordering of amino acid side-chains into a well defined and closely packed configuration. We review a number of topics related to this process. We first describe how the observed packing in protein crystal structures is measured.
M, Levitt +4 more
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Classification of Protein Folds
Molecular Biotechnology, 2002The diversity and complexity of bioinformatics tools currently available for protein sequence analysis can make it difficult to know where to begin when presented with a new sequence. In this article, we present a protocol outlining one approach to sequence analysis that should give as comprehensive a picture as possible as to the likely structure and ...
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Protein folding on the ribosome
Current Opinion in Structural Biology, 2010In living systems, polypeptide chains are synthesised on ribosomes, molecular machines composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from the ribosomal exit tunnel and into the cellular environment, the majority must fold into specific structures in order to function.
Lisa D, Cabrita +2 more
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