Results 241 to 250 of about 6,828,531 (409)

The case for defined protein folding pathways

Proceedings of the National Academy of Sciences of the United States of America, 2017
S. Englander, L. Mayne
semanticscholar   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Heat shock proteins in protein folding and reactivation. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Malkeyeva D, Kiseleva EV, Fedorova SA.
europepmc   +1 more source

A stably folded presecretory protein associates with and upon unfolding translocates across the membrane of mammalian microsomes [PDF]

, 1994
Gabriel Schlenstedt, Maria Zimmermann, Richard Zimmermann   +2 more
openalex   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

More than Just Protein Folding: The Epichaperome, Mastermind of the Cancer Cell. [PDF]

Cells
Amissah HA, Antwi MH, Amissah TA, Combs SE, Shevtsov M.   +4 more
europepmc   +1 more source

Metamorphic protein folding as evolutionary adaptation. [PDF]

Trends Biochem Sci, 2023
Dishman AF, Volkman BF.
europepmc   +1 more source

Artificial duplication of the R67 dihydrofolate reductase gene to create protein asymmetry. Effects on protein activity and folding.

, 1993
Pengzhe Zhuang, Miao Yin, Janel C. Holland, Cynthia B. Peterson, Elizabeth E. Howell   +4 more
openalex   +1 more source

Inhibitor‐2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase‐1 into a conformation with the specificity and regulatory properties of the native enzyme [PDF]

, 1993
Dario R. Alessi, Alasdair J. Street, Philip Cohen, Patricia T.W. Cohen   +3 more
openalex   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source