Results 241 to 250 of about 6,834,568 (390)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Unsupervised Learning of Progress Coordinates during Weighted Ensemble Simulations: Application to NTL9 Protein Folding. [PDF]

J Chem Theory Comput
Leung JMG, Frazee NC, Brace A, Bogetti AT, Ramanathan A, Chong LT.   +5 more
europepmc   +1 more source

Metamorphic protein folding as evolutionary adaptation. [PDF]

Trends Biochem Sci, 2023
Dishman AF, Volkman BF.
europepmc   +1 more source

Energy landscape in protein folding and unfolding

Proceedings of the National Academy of Sciences of the United States of America, 2016
F. Mallamace, C. Corsaro, D. Mallamace, S. Vasi, C. Vasi, P. Baglioni, S. Buldyrev, Sow-Hsin Chen, H. Stanley, A. Nilsson, M. Parrinello, S. C   +11 more
semanticscholar   +1 more source

Proteins will Fold Anyway!! [PDF]

Journal of Biomolecular Structure and Dynamics, 2011
openaire   +3 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Isoleucine Side Chains as Reporters of Conformational Freedom in Protein Folding Studied by DNP-Enhanced NMR. [PDF]

J Am Chem Soc
Levorin L, Becker N, Uluca-Yazgi B, Gardon L, Kraus M, Sevenich M, Apostolidis A, Schmitz K, Rüter N, Apanasenko I, Willbold D, Hoyer W, Neudecker P, Gremer L, Heise H.   +14 more
europepmc   +1 more source

Protein folding rate evolution upon mutations. [PDF]

Biophys Rev, 2023
Vila JA.
europepmc   +1 more source

Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase

, 1993
Jeffrey R. Huth, Fulvio Perini, Oksana Lockridge, Elliott Bedows, Raymond W. Ruddon   +4 more
openalex   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source