Results 111 to 120 of about 1,237,822 (372)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]

, 2019
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
core  

A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks [PDF]

, 2005
Background Transcription regulatory networks are composed of interactions between transcription factors and their target genes. Whereas unicellular networks have been studied extensively, metazoan transcription regulatory networks remain largely ...
Deplancke, B., Grove, C.A., Hope, I.A., Reece-Hoyes, J.S., Shingles, J., Walhout, J.M.   +5 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems. [PDF]

PLoS ONE, 2010
BACKGROUND: Nuclear Magnetic Resonance (NMR) spectroscopy offers a variety of experiments to study protein-ligand interactions at atomic resolution. Among these experiments, 15N Heteronuclear Single Quantum Correlation (HSQC)experiment is simple, less ...
Janarthanan Krishnamoorthy, Victor C K Yu, Yu-Keung Mok   +2 more
doaj   +1 more source

A human MAP kinase interactome. [PDF]

, 2010
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other ...
A Friedman, A Karydis, A Lunardi, AA Reszka, AC Gavin, AJ Whitmarsh, BP Kelley, C Widmann, Chih-yuan Chiang, Christopher H Martin, Cornelia Kurschner, D Wang, Diane L Barber, DJ LaCount, GD Bader, GL Johnson, J Kim, J Ptacek, JV Olsen, Jyoti Srivastava, K Hayashi, K Venkatesan, KC Gunsalus, L Chang, L Collin, M Baumgartner, M Karin, M Qi, M Rothe, Merril Gersten, Mike Smoot, P Uetz, PJ Cullen, R Hooley, R Konig, R Konig, R Konig, Russell Bell, S Peri, SA Johnson, SK Chanda, Sourav Bandyopadhyay, SP Denker, Sudhir Sahasrabudhe, Suhaila White, Sumit K Chanda, T Ito, T Reguly, Trey Ideker, W Kolch, W Kolch, Y Ho   +51 more
core   +3 more sources

Mapping the Protein Interaction Landscape for Fully Functionalized Small-Molecule Probes in Human Cells

Journal of the American Chemical Society, 2014
Phenotypic screening provides a means to discover small molecules that perturb cell biological processes. Discerning the proteins and biochemical pathways targeted by screening hits, however, remains technically challenging. We recently described the use
Tohru Kambe, B. Correia, M. Niphakis, B. Cravatt   +3 more
semanticscholar   +1 more source

Building protein interaction maps for Down's syndrome [PDF]

Briefings in Functional Genomics and Proteomics, 2004
Now that the complete sequences for human chromosome 21 and the orthologous mouse genomic regions are known, reasonably complete, conserved, protein-coding gene catalogues are also available. The central issue now facing Down's syndrome researchers is the correlation of increased expression of specific, normal, chromosome 21 genes with the development ...
Gardiner, K, Davisson, M T, Crnic, L S
openaire   +3 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Mapping additive and epistatic QTLs for forage quality and yield in soybean [Glycine max (L.) Merri.] in two environments

Biotechnology & Biotechnological Equipment, 2021
Soybean plants have high protein content and can be used as a supplementary source of high-protein feed. To map quantitative trait loci (QTL) for the content of crude protein (CP), neutral detergent fibre (NDF), acid detergent fibre (ADF) and dry weight ...
Guofu Hu, Bo Wang, Ting Gong, Ran Li, Xin Guo, Wei Liu, Zouzhuan Yang, Chunyan Liu, Wen-Xia Li, Hailong Ning   +9 more
doaj   +1 more source