Results 141 to 150 of about 2,092,635 (263)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Protein Kinase Inhibitors and Oxidative Stress Modulate In Vivo Phosphorylation of <i>Trypanosoma cruzi</i> DNA Polymerase β. [PDF]

Pharmaceutics
Maldonado E, Oyarce M, Canobra P, Rojas E, Urbina F, Tapia JC, Jara L, Miralles VJ, Castillo C, Solari A.   +9 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYRK1B. [PDF]

Sci Rep
Detro-Dassen S, Schwandt K, Helmich P, Düsterhöft S, Becker W.   +4 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Atypical protein kinase C activation drives intestinal glucose excretion in diabetes mellitus. [PDF]

Nat Commun
Kang CW, Hong ZY, Oh JH, Farh ME, Wang EK, Lee S, Kang UH, Nam JH, Lee YJ, Shin H, Kim YB, Jeon H, Jeong JW, Kim D, Kim JS, Hong SS, Park JP, Cho HJ, Fang S, Kim HH, Cho A, Lim BK, Sohn I, Ku CR.   +23 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Bioinformatic analysis and experimental validation of the function of mitogen-activated protein kinase in esophageal cancer. [PDF]

Discov Oncol
Zhu X, Zhu G, Guo T, Min W, Li X.
europepmc   +1 more source

Mitogen-Activated Protein Kinase Kinase Kinase 13 [PDF]

, 2020
openaire   +1 more source