Results 191 to 200 of about 3,503,537 (407)
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
A new protein kinase cascade [PDF]
Nature Reviews Molecular Cell Biology, 2014 openaire +3 more sources
Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils [PDF]
, 2007 Arash S. Saffar +4 more
openalex +1 more source
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A.
Molecules and Cells, 1999 H. Harada +8 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity [PDF]
, 2016 Pei F. Lai +2 more
openalex +1 more source
Clustering of colon, lung, and other cancer susceptibility genes with protein tyrosine phosphatases and protein kinases in multiple short genomic regions [PDF]
, 2023 Lei Quan, Peter Démant
openalex +1 more source