Results 211 to 220 of about 2,191,855 (361)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Identification of viral activators of the HSV-2 UL13 protein kinase. [PDF]

J Virol
Koyanagi N, Takeshima K, Shio S, Maruzuru Y, Kato A, Kawaguchi Y.   +5 more
europepmc   +1 more source

Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits

, 2015
Gregory S. Hoeker, Mohamed A. Hanafy, Robert A. Oster, Donald M. Bers, Steven M. Pogwizd   +4 more
openalex   +1 more source

Effects of dietary corticosterone on the central adenosine monophosphate-activated protein kinase (AMPK) signaling pathway in broiler chickens

, 2020
Xiyi Hu, Yuanli Cai, Linglian Kong, Hai Lin, Zhigang Song, Johan Buyse   +5 more
openalex   +2 more sources

Involvement of Protein Kinase A in Nitric Oxide Stimulating Effect on a BKCa Channel of Human Dermal Fibroblasts [PDF]

, 2007
Si Young Roh, Seyong Choi, Inja Lim
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The oncogene protein kinase PIM1 regulates mammalian erythroblast enucleation. [PDF]

Commun Biol
Zhang H, Xu Y, Li Y, Zhang J, Xiao J, Wang C, Wang Y, An X, Zhang S.   +8 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions. [PDF]

MedComm (2020)
Li Y, Jiang Y, Hu Z, Yang S, Li L, Xiong C, Gao Y, Sun W, Zhang Y.   +8 more
europepmc   +1 more source