Results 221 to 230 of about 2,191,855 (361)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Mitogen-activated protein kinase (MAPK) gene family identification reveals GhMPK10-mediated regulation of abiotic stress tolerance through protein kinase signaling cascades in cotton. [PDF]

BMC Plant Biol
Li Y, Su R, Wang K, Wang J, Zhang D.
europepmc   +1 more source

Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes [PDF]

, 1997
Guillermo Velasco, Manuel Guzmán, Victor A. Zammit, Math J.H. Geelen   +3 more
openalex   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Systems modeling and uncertainty quantification of AMP-activated protein kinase signaling. [PDF]

NPJ Syst Biol Appl
Linden-Santangeli N, Zhang J, Kramer B, Rangamani P.   +3 more
europepmc   +1 more source

A protein kinase switch [PDF]

Genome Biology, 2000
openaire   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Knockdown of Serine-Arginine Protein Kinase 3 Impairs Sperm Development in <i>Spodoptera frugiperda</i>. [PDF]

Insects
Song Y, Zhou Y, Wang R, Zhang B, Li Z, Liu X, Li D.   +6 more
europepmc   +1 more source

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways

, 2018
Zi-Han Tian, Jueng-Tsueng Weng, Li‐Jane Shih, An-Ci Siao, Tsai-Yun Chan, Yi-Wei Tsuei, Yow-Chii Kuo, Tsu-Shing Wang, Yung-Hsi Kao   +8 more
openalex   +2 more sources

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans [PDF]

, 2018
Stefan Lutz, Mathias Falcenberg, Fausto Machicao, Andreas Peter, Martin Kächele, Elko Randrianarisoa, Angela Lehn‐Stefan, Róbert Wágner, Jürgen Machann, Fritz Schick, Martin Heni, Axel Ullrich, Andreas Fritsche, Norbert Stefan, Hans‐Ulrich Häring, Harald Staiger, Kοnstantinos Kantartzis   +16 more
openalex   +1 more source