Results 261 to 270 of about 5,161,634 (390)

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Constructing Photoactive Au NP/MXene-BiOCl Moiré Superlattice Nanosheets for Photoelectrochemical Detection of Protein Kinase Activity. [PDF]

Int J Mol Sci
Li Y, Chen J, Yang C, Fan W, Chen Q, Yang N, Deng P, Zhai W, Yan Z, Wang F.   +9 more
europepmc   +1 more source

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

Advanced Biology, EarlyView.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André, Nikita Rehnberg, Ankush Garg, Magnus Kjærgaard   +3 more
wiley   +1 more source

Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N. [PDF]

Commun Biol
Bogomolovas J, Chen J.
europepmc   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses. [PDF]

Front Plant Sci
Shi Y, Zhang Z, Yan Z, Chu H, Luo C.
europepmc   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells. [PDF]

Sci Rep
Noguchi A, Kimura M, Saiki Y, Ishikawa T, Kokumai T, Omori Y, Ono Y, Miszukami Y, Ishida M, Mizuma M, Nakagawa K, Unno M, Furukawa T.   +12 more
europepmc   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Spatiotemporal profiling of protein kinase A activity in spontaneously beating hiPSC-derived cardiac organoids. [PDF]

iScience
Weiser-Bitoun I, Mazgaoker S, Eid R, Brosh I, Yaniv Y.   +4 more
europepmc   +1 more source