Results 271 to 280 of about 2,152,541 (363)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway. [PDF]

J Tradit Chin Med
Weijia LI, Jing LU, Chao MA, Mengmeng L, Ke P, Hongyan C, Zhe L, Guangfu L.   +7 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Critical role of the β isoform of protein kinase C (PKCβ) in angiotensin II-induced oxidative stress in vascular smooth muscle cells. [PDF]

Physiol Rep
Tajima H, Naganishi S, Mukohda M, Ishida M, Hamada N, Shigemi N, Yamasaki T, Nakamura S, Matsui T, Mizuno R, Ozaki H.   +10 more
europepmc   +1 more source

Depressed cardiac cyclic GMP-dependent protein kinase in spontaneously hypertensive rats and its further depression by guanethidine

, 1976
J.F. Kuo, Craig W. Davis, James Tse
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Protein Kinase Activity from Vaccinia Virions: Solubilization and Separation into Heat-Labile and Heat-Stable Components

, 1973
Jay H. Kleiman, Bernard Moss
openalex   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Jingui Shenqi pill ( ) treats cardiorenal syndrome by inhibiting mitogen-activated protein kinase signaling pathway and reducing inflammatory response. [PDF]

J Tradit Chin Med
Shuyan H, Xinyue D, Hui Z, Zongjun L, Yuling L, Lina X.   +5 more
europepmc   +1 more source

Effect of adenosine 3′,5′-cyclic monophosphate derivatives on α-amylase release, protein kinase and cyclic nucleotide phosphodiesterase activity from rat parotid tissue

, 1976
Fred R. Butcher, Molly Thayer, John M. Goldman   +2 more
openalex   +1 more source