Results 291 to 300 of about 2,670,458 (365)

Protein Kinase A

Definitions, 2020
Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/T hr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homoor ...

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A-kinase anchoring proteins: protein kinase A and beyond

Current Opinion in Cell Biology, 2000
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs).
Amelia S. Edwards, John D. Scott
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Protein kinases

Current Opinion in Structural Biology, 1994
The structures of four serine/threonine protein kinases have been determined recently. By comparing these structures with that of the cAMP-dependent protein kinase (cAPK), it is now possible to see how the activity of these regulatory enzymes is controlled. Low activity is maintained through the conformation of the phosphorylation lip, domain rotations,
E J, Goldsmith, M H, Cobb
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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

Science, 1988
In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino ...
S. Hanks, A. Quinn, T. Hunter
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AGC protein kinase phosphorylation and protein kinase C

Biochemical Society Transactions, 2001
Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events?
Parker, P J, Parkinson, S J
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Protein Kinase C

Journal of Cellular Physiology, 1986
The combined application of protein structural techniques, immunochemistry, and molecular biology has permitted an analysis of the differential expression of the genes for the three related protein kinases, C-alpha, -beta, and gamma. The evidence now suggests that the type of protein kinase C in a cell may govern the nature and mechanisms of functional
Axel Ullrich, Peter J. Parker
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Aging and Protein Kinases

2021
Recently, aging has been tried to be explained with large numbers of theories, but none of them can elucidate the changes occurring in the aging process alone. A unified theory encompassing the mechanisms of genetic factors and repair systems in aging is becoming increasingly required.
ENGİN, ATİLLA, ENGİN, AYŞE BAŞAK
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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.

Science, 1992
Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca2+ channels. This was once thought to be the sole mechanism to produce the diacylglycerol that links extracellular signals to ...
Y. Nishizuka
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