Results 71 to 80 of about 3,503,537 (407)

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder

Frontiers in Pharmacology, 2015
Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren, Patrick J Nygren, John D. Scott, John D. Scott   +3 more
doaj   +1 more source

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

eLife, 2020
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia   +13 more
doaj   +1 more source

Fyn-Mediated Regulation of Protein Kinase A [PDF]

, 2017
Protein kinases are enzymes important for signal transduction in the regulation of cellular processes. The cAMP-dependent protein kinase A (PKA) has been previously reported to regulate the activity of the Src family kinase Fyn, an event important for ...
Barritt, Sam
core   +1 more source

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg, Adams, Alexander, Bardwell, Barsyte-Lovejoy, Bhattacharyya, Bhattacharyya, Buschbeck, Caffrey, Cavanaugh, Chang, Chen, Coulombe, Drew, Emsley, Garai, Guo, Gupta, Gógl, Hayashi, Hu, Jacobs, Kabsch, Kato, Kato, Kondoh, Li, Liu, Liu, Liu, Ma, McCoy, Milanesi, Moscat, Murakami, Nakamura, Nakamura, Nakamura, Nishimoto, Pearson, Piserchio, Potthoff, Raman, Ranganathan, Regan, Reményi, Sharrocks, Sohn, Tanoue, Wang, Watson, Winn, Won, Zarrinpar, Zeke, Zhang, Zhou, Zhou   +57 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A One-Week Laboratory Practice: Introducing the Students to the Study of Plant Biochemistry and Signal Transduction [PDF]

, 2000
This report describes a one-week laboratory practice for students. An approach to study a Calcium dependent protein kinase (CDPK) involved in signal transduction processes in potato plants, is undertaken.
Raices, Marcela, Tellez, Maria Teresa, Ulloa, Rita Maria   +2 more
core  

Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. [PDF]

, 2020
Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway.
Bin, Hu, Chan, Geraldine, Jablons, David M, Kyoyama, Hiroyuki, Li, Hui, Liu, Luwei, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Wang, Yucheng, Xu, Zhidong, Yang, Yi-Lin, You, Liang   +12 more
core  

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Differential Downregulation of β1‐Adrenergic Receptor Signaling in the Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (β1AR) in heart failure. We aim to explore the differential downregulation subcellular pools of β1AR signaling in the heart.
Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang   +6 more
doaj   +1 more source