Results 71 to 80 of about 5,161,634 (390)

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Differential Downregulation of β1‐Adrenergic Receptor Signaling in the Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (β1AR) in heart failure. We aim to explore the differential downregulation subcellular pools of β1AR signaling in the heart.
Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang   +6 more
doaj   +1 more source

AKAP6 and phospholamban colocalize and interact in HEK‐293T cells and primary murine cardiomyocytes

Physiological Reports, 2019
Phospholamban (PLN) is an important Ca2+ modulator at the sarcoplasmic reticulum (SR) of striated muscles. It physically interacts and inhibits sarcoplasmic reticulum Ca2+ ATPase (SERCA2) function, whereas a protein kinase A (PKA)‐dependent ...
Farigol Hakem Zadeh, Allen C. T. Teng, Uros Kuzmanov, Paige J. Chambers, Allan R. Tupling, Anthony O. Gramolini   +5 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

EMBO Journal, 2001
Spatiotemporal regulation of protein kinase A (PKA) activity involves the manipulation of compartmentalized cAMP pools. Now we demonstrate that the muscle‐selective A‐kinase anchoring protein, mAKAP, maintains a cAMP signaling module, including PKA and ...
K. Dodge, Samone Khouangsathiene, M. Kapiloff, Robert E Mouton, E. Hill, M. Houslay, L. Langeberg, John D. Scott   +7 more
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder

Frontiers in Pharmacology, 2015
Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren, Patrick J Nygren, John D. Scott, John D. Scott   +3 more
doaj   +1 more source

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs).
D. T. Dudley, L. Pang, S. Decker, A. Bridges, A. Saltiel   +4 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Protein Kinase A Anchoring [PDF]

Journal of Biological Chemistry, 1997
Specificity is perhaps the most enigmatic property of hormonemediated signaling pathways, especially when one considers that more than 30 hormones employ the ubiquitous second messengers, Ca, phospholipid, or cAMP, to relay messages from the cell membrane to intracellular effectors.
Mark L. Dell'Acqua, John D. Scott
openaire   +3 more sources