Results 81 to 90 of about 2,191,855 (361)

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation

Journal of Lipid Research, 2016
The endocannabinoids and their main receptor, cannabinoid type-1 (CB1), suppress intracellular cyclic AMP levels and have emerged as key players in the control of energy metabolism.
Lucia M. Krott, Fabiana Piscitelli, Markus Heine, Simona Borrino, Ludger Scheja, Cristoforo Silvestri, Joerg Heeren, Vincenzo Di Marzo   +7 more
doaj   +1 more source

Allosteric cooperativity in protein kinase A [PDF]

Proceedings of the National Academy of Sciences, 2008
Allosteric signaling in proteins requires long-range communication mediated by highly conserved residues, often triggered by ligand binding. In this article, we map the allosteric network in the catalytic subunit of protein kinase A using NMR spectroscopy.
Larry R, Masterson, Alessandro, Mascioni, Nathaniel J, Traaseth, Susan S, Taylor, Gianluigi, Veglia   +4 more
openaire   +2 more sources

Modulation by cAMP of a Slowly Activating Potassium Channel Expressed in \u3cem\u3eXenopus\u3c/em\u3e Oocytes [PDF]

, 1992
When expressed in the Xenopus oocyte, the minK protein induces a slowly activating voltage-dependent potassium current (Isk). We studied the modulation of this current by altering intracellular cAMP levels and found that the amplitude of Isk is ...
Blumenthal, Edward M, Kaczmarek, Leonard K.   +1 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

eLife, 2019
The cAMP-dependent protein kinase A (PKA) regulates various cellular functions in health and disease. In endothelial cells PKA activity promotes vessel maturation and limits tip cell formation.
Xiaocheng Zhao, Pavel Nedvetsky, Fabio Stanchi, Anne-Clemence Vion, Oliver Popp, Kerstin Zühlke, Gunnar Dittmar, Enno Klussmann, Holger Gerhardt   +8 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Dynamic architecture of a protein kinase [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Protein kinases represent a critically important family of regulatory enzymes. Their activity can be altered by mutations and binding events distant from the active site. To understand the nature of these long-distance effects, we used microsecond-timescale molecular dynamic simulation to subdivide a prototypical kinase, protein ...
McClendon, Christopher L, Kornev, Alexandr P, Gilson, Michael K, Taylor, Susan S   +3 more
openaire   +4 more sources

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways [PDF]

, 2007
Migration and proliferation of smooth muscle cells are key to a number of physiological and pathological processes, including wound healing and the narrowing of the vessel wall.Previous work has shown links between inflammatory stimuli and vascular ...
Agnes Czibula, Andrea R. King, Anthony G. Wilson, Bonventre, Che, Choukroun, David C. Crossman, Du, Emily Heath, Endre Kiss-Toth, Force, Goldschmidt, Grosshans, Hegedus, Hegedus, Hongtao Guan, Hye Youn Sung, Iynedjian, Jones, Ju, Katalin Eder, King, Kiss-Toth, Kiss-Toth, Kiss-Toth, Koo, Lai, Levchenko, Li, Majesky, Mata, McCarthy, Michnick, Mii, Morton, Ohoka, Remy, Remy, Robinson, S. Kim Suvarna, Saka, Sato, Satterthwaite, Schwarzer, Seher, Sheila E. Francis, Stary, Stary, Stary, Steven K. Dower, Surapisitchat, Takeishi, Touyz, Warner, Wilkin, Xia, Yamakawa, Yang, Yue   +58 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source