Results 61 to 70 of about 79,392 (254)

Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79

Sensors, 2018
Fluorescence resonance energy transfer (FRET)-based sensors for 3′–5′cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) allow real-time imaging of cAMP levels and kinase activity in intact cells with high spatiotemporal ...
Nshunge Musheshe, Miguel J. Lobo, Martina Schmidt, Manuela Zaccolo   +3 more
doaj   +1 more source

Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits

PLoS ONE, 2013
3',5'-cyclic adenosine monophosphate (cAMP) dependent protein kinase or protein kinase A (PKA) has served as a prototype for the large family of protein kinases that are crucially important for signal transduction in eukaryotic cells. The PKA catalytic subunits Cα and Cβ, encoded by the two genes PRKACA and PRKACB, respectively, are among the best ...
Søberg, Kristoffer, Jahnsen, Tore, Rognes, Torbjørn, Skålhegg, Bjørn Steen, Lærdahl, Jon Kristen   +4 more
openaire   +5 more sources

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Molecular evolution of a-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization

BMC Evolutionary Biology, 2012
Background A-Kinase Anchoring Proteins (AKAPs) are molecular scaffolding proteins mediating the assembly of multi-protein complexes containing cAMP-dependent protein kinase A (PKA), directing the kinase in discrete subcellular locations.
Johnson Keven R, Nicodemus-Johnson Jessie, Carnegie Graeme K, Danziger Robert S   +3 more
doaj   +1 more source

Phosphorylation-Dependent SERS Readout for Activity Assay of Protein Kinase A in Cell Extracts

Nanomaterials, 2020
Protein kinases are key regulators of cell function, the abnormal activity of which may induce several human diseases, including cancers. Therefore, it is of great significance to develop a sensitive and reliable method for assaying protein kinase ...
Renyong Liu, Chenggen Xie, Yehan Yan, Lin Hu, Suhua Wang, Khalid A. Alamry, Hadi M. Marwani, Lijuan Chen   +7 more
doaj   +1 more source

A Novel Murine PKA-Related Protein Kinase Involved in Neuronal Differentiation

Genomics, 2000
Members of the cAMP-dependent second-messenger pathway have been described as regulators of cellular growth and differentiation and were consequently implicated in a variety of embryogenic processes including brain development. Moreover, recent data suggest an indispensable role for cAMP-dependent protein kinases (PKAs) in neuronal differentiation and ...
R J, Blaschke, A P, Monaghan, D, Bock, G A, Rappold   +3 more
openaire   +2 more sources

An A-kinase anchoring protein (ACBD3) coordinates traffic-induced PKA activation at the Golgi

Journal of Biological Chemistry, 2023
KDEL receptor (KDELR) is a key protein that recycles escaped endoplasmic reticulum (ER) resident proteins from the Golgi apparatus back to the ER and maintains a dynamic balance between these two organelles in the early secretory pathway. Studies have shown that this retrograde transport pathway is partly regulated by two KDELR-interacting proteins ...
Jie Jia, Shuocheng Tang, Xihua Yue, Shuaiyang Jing, Lianhui Zhu, Chuanting Tan, Jingkai Gao, Yulei Du, Intaek Lee, Yi Qian   +9 more
openaire   +2 more sources

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A

Proteomes, 2018
The cAMP-dependent protein kinase A (PKA) is a serine/threonine kinase involved in many fundamental cellular processes, including migration and proliferation.
Anna M. Schmoker, Samuel A. Barritt, Marion E. Weir, Jacqueline E. Mann, Tyler C. Hogan, Bryan A. Ballif, Paula B. Deming   +6 more
doaj   +1 more source

Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism. [PDF]

PLoS ONE, 2011
Autism is a severe neurodevelopmental disorder that is characterized by impaired language, communication, and social skills. In regressive autism, affected children first show signs of normal social and language development but eventually lose these ...
Lina Ji, Ved Chauhan, Michael J Flory, Abha Chauhan   +3 more
doaj   +1 more source