Results 61 to 70 of about 145,066 (299)
CellsProtein kinase A (PKA), commonly referred to as cAMP-dependent protein kinase, exists as a heterotetramer composed of two catalytic (C) and regulatory subunits (R).
Fang Xu +11 more
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Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein. [PDF]
PLoS Pathogens, 2016 The oncoproteins of the small DNA tumor viruses interact with a plethora of cellular regulators to commandeer control of the infected cell. During infection, adenovirus E1A deregulates cAMP signalling and repurposes it for activation of viral gene ...
Cason R King +5 more
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Journal of Fungi, 2022 Morphogenesis is a strictly regulated efficient system in eukaryotes for adapting to environmental changes. However, the morphogenesis regulatory mechanism in smut fungi is not clear.
Enping Cai +7 more
doaj +1 more source
Phase-dependent molecular requirements for memory reconsolidation: differential roles for protein synthesis and protein kinase A activity [PDF]
, 2006 After consolidation, a process that requires gene expression and protein synthesis, memories are stable and highly resistant to disruption by amnestic influences.
Kemenes, György +4 more
core +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease
Signal Transduction and Targeted TherapyDisrupted lipogenic signaling and steatosis are key features of alcohol-associated liver disease (ALD). A-kinase anchoring protein 12 (AKAP12) is a scaffolding partner of the cAMP-dependent protein kinase, PKA that controls its spatiotemporal ...
Chandana Thimme Gowda +6 more
doaj +1 more source
Impact of kinase activating and inactivating patient mutations on binary PKA interactions
Frontiers in Pharmacology, 2015 The second messenger molecule cAMP links extracellular signals to intracellular responses. The main cellular cAMP effector is the compartmentalized protein kinase A (PKA).
Ruth eRöck +3 more
doaj +1 more source
Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. [PDF]
, 2018 G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in a broad range of physiological responses and disease states. Activated GPCRs can undergo agonist-induced phosphorylation by G protein receptor kinases (GRKs) and second ...
Chowdhury, Dhrubajyoti +8 more
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Progesterone inhibits protein kinase A (PKA) inXenopusoocytes: demonstration of endogenous PKA activities using an expressed substrate [PDF]
Journal of Cell Science, 2004 3′-5′ cyclic adenosine monophosphate (cAMP)-dependent protein kinase, PKA, is thought to be a key enzyme that controls prophase arrest in vertebrate oocytes. It has long been established that overexpression of the catalytic subunit of PKA inhibits hormone-induced frog oocyte maturation whereas overexpression of the regulatory subunits induces hormone ...
Jing, Wang, X Johné, Liu
openaire +2 more sources
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source