Results 171 to 180 of about 3,162,793 (373)

Glycogen Synthase Kinase-3 Beta (GSK3β) as a Potential Drug Target in Regulating Osteoclastogenesis: An Updated Review on Current Evidence

Biomolecules
Glycogen synthase kinase 3-beta (GSK3β) is a highly conserved protein kinase originally involved in glucose metabolism, insulin activity, and energy homeostasis.
Sok Kuan Wong
doaj   +1 more source

Glucose Uptake in the Human Pathogen Schistosoma mansoni Is Regulated Through Akt/Protein Kinase B Signaling [PDF]

, 2017
Maxine McKenzie, Ruth S. Kirk, Anthony J. Walker   +2 more
openalex   +1 more source

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

Proceedings of the National Academy of Sciences of the United States of America, 1998
Marc Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett, S. Dedhar   +5 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The effect of curcumin on PI3K/Akt and AMPK pathways in insulin resistance induced by fructose

Türk Biyokimya Dergisi
Excessive fructose consumption is recognized to elevate insulin resistance in animals and humans. In our study, we aimed to assess the possible consequences of curcumin (curc) treatment applied to rat models of fructose-induced insulin resistance on ...
Kiren Gülce, Severcan Çınar, Severcan Suzan Muratoğlu, Paşaoğlu Hatice   +3 more
doaj   +1 more source

Utilisation of Oocyte Diameter as a Non-invasive Indicator of Oocyte and Embryo Quality: Investigating Protein Kinase B Protein Expression in Cumulus–Granulosa Cells and Embryo Morphokinetics

Journal of Human Reproductive Sciences
Background: Oocyte diameter is crucial for initiating meiosis and supporting the maturation capability, a prerequisite for successful fertilisation and high-quality embryo development.
Tita Yuningsih, Budi Wiweko, Arief Boediono, Ina Gunawati, Nining Handayani   +4 more
doaj   +1 more source

Protein kinase B (PKB; PKBA; AKT; AKT1) [PDF]

, 2014

openalex   +1 more source

Supplementary Table 1 from Inhibition of <i>S</i>-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

, 2023
Dana‐Lynn T. Koomoa, Tamás Borsics, David J. Feith, Craig C. Coleman, Christopher J. Wallick, Ivonne Gamper, Anthony E. Pegg, André S. Bachmann   +7 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

MAST Kinases’ Function and Regulation: Insights from Structural Modeling and Disease Mutations

Biomedicines
Background/Objectives: The MAST kinases are ancient AGC kinases associated with many human diseases, such as cancer, diabetes, and neurodevelopmental disorders.
Michael C. Lemke, Nithin R. Avala, Michael T. Rader, Stefan R. Hargett, Daniel S. Lank, Brandon D. Seltzer, Thurl E. Harris   +6 more
doaj   +1 more source