Results 171 to 180 of about 2,888,198 (397)
Cancer Management and Research, 2020 Zhaoxia Wang,1 Fengyan Li,1 Meiyan Wei,1 Sanyuan Zhang,1 Tong Wang2 1Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of Health Statistics, School of Public Health ...
Wang Z, Li F, Wei M, Zhang S, Wang T
doaj
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
The effect of exercise intervention on angiogenesis gene expression (inducing and inhibiting factors) following myocardial ischemia-reperfusion [PDF]
فصلنامه ابن سینا, 2017 Background: Angiogenic process is vital to cure the injured parts of the heart. This study was conducted with the aim to investigate the effect of exercise intervention on the expression of inducing and inhibiting factors involved in the angiogenic and ...
Y Mehrialvar +4 more
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Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
The effect of curcumin on PI3K/Akt and AMPK pathways in insulin resistance induced by fructose
Türk Biyokimya DergisiExcessive fructose consumption is recognized to elevate insulin resistance in animals and humans. In our study, we aimed to assess the possible consequences of curcumin (curc) treatment applied to rat models of fructose-induced insulin resistance on ...
Kiren Gülce +3 more
doaj +1 more source
Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. [PDF]
, 1992 Paul R. Clarke +3 more
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Characterization of distinct tyrosine-specific protein kinases in B and T lymphocytes
, 1985 openalex +2 more sources
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Interferon-gamma gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation [PDF]
, 1992 Yanbo Pang +4 more
openalex +1 more source