Results 11 to 20 of about 1,202,909 (308)

Protein kinase B [PDF]

Current Biology, 2000
Vanhaesebroeck B, Alessi, DR: The PI3K-PDK1 connection: more than just a road to PKB.Biochem J 2000, 346:561-576.Scheid MP, Woodgett JR: Protein kinases: six degrees of separation?Curr Biol 2000, 10:R191-R194.Coffer P, Jin J, Woodgett JR: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.Biochem J 1998 ...
openaire   +2 more sources

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Journal of Lipid Research, 2015
Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which ...
Mini P. Sajan, Robert A. Ivey, Mackenzie C. Lee, Robert V. Farese   +3 more
doaj   +1 more source

Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Protein kinases (PKs) are one of the largest protein families in most eukaryotic organisms. These enzymes are involved in the control of cell proliferation, differentiation and metabolism and a large number of the anticancer drugs currently used are ...
Marion Morel, Mathieu Vanderstraete, Katia Cailliau, Arlette Lescuyer, Julien Lancelot, Colette Dissous   +5 more
doaj   +1 more source

Role of RAS signaling in ovarian cancer [version 1; peer review: 2 approved]

F1000Research, 2022
The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning ...
Hesham M. Korashy, Shahab Uddin, Abdullah Azmi, Ajaz Bhat, Lubna Therachiyil, Anjana Anand   +5 more
doaj   +1 more source

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK

Frontiers in Pharmacology, 2022
Hyperactivation of Bruton’s tyrosine kinase (BTK) or interleukin-2-inducible T cell kinase (ITK) has been attributed to the pathogenesis of B-cell lymphoma or T-cell leukemia, respectively, which suggests that Bruton’s tyrosine kinase and interleukin-2 ...
Peiran Song, Peiran Song, Gang Bai, Shingpan Chan, Tao Zhang, Linjiang Tong, Yi Su, Yanyan Shen, Yi Chen, Yingqiang Liu, Mengzhen Lai, Mengzhen Lai, Yi Ning, Haotian Tang, Yan Fang, Yi Chen, Ke Ding, Jian Ding, Jian Ding, Hua Xie, Hua Xie, Hua Xie   +21 more
doaj   +1 more source

Protein kinase B/Akt at a glance [PDF]

Journal of Cell Science, 2005
Among the signalling proteins that respond to a large variety of signals, protein kinase B (PKB, also known as Akt) appears to be a central player in regulation of metabolism, cell survival, motility, transcription and cell-cycle progression.
Elisabeth, Fayard, Lionel A, Tintignac, Anne, Baudry, Brian A, Hemmings   +3 more
openaire   +2 more sources

Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications

Frontiers in Endocrinology, 2019
Accumulating evidence indicates the occurrence and development of diabetic complications relates to not only constant high plasma glucose, but also glucose fluctuations which affect various kinds of molecular mechanisms in various target cells and ...
Zhen-Ye Zhang, Ling-Feng Miao, Ling-Ling Qian, Ning Wang, Miao-Miao Qi, Yu-Min Zhang, Shi-Peng Dang, Ying Wu, Ru-Xing Wang   +8 more
doaj   +1 more source

Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage

Virulence, 2021
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao, Zheng Chen   +5 more
doaj   +1 more source

Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies

Pharmaceuticals, 2022
Death-associated protein kinase 1 (DAPK1) is a serine/threonine protein kinase involved in diverse fundamental cellular processes such as apoptosis and autophagy.
Ahmed Elkamhawy, Sora Paik, Eslam M. H. Ali, Ahmed H. E. Hassan, So Jin Kang, Kyeong Lee, Eun Joo Roh   +6 more
doaj   +1 more source

Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library

Molecules, 2019
As aberrant activity of protein kinases is observed in many disease states, these enzymes are common targets for therapeutics and detection of activity levels.
Dongwook Kim, Yixing Sun, Dan Xie, Kyle E. Denton, Hao Chen, Hang Lin, Michael K. Wendt, Carol Beth Post, Casey J. Krusemark   +8 more
doaj   +1 more source