Results 11 to 20 of about 1,944,084 (333)

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity [PDF]

, 2011
The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex.
Alban Ordureau, Banchereau, Bessa, Boone, Cheung, Chu, Conze, David W. Powell, Döffinger, Ea, El Bakkouri, Haas, Han, He, He, Heyninck, Heyninck, Hwang, Inohara, J. Simon C. Arthur, Janet C. Patterson-Kane, Kanayama, Kawagoe, Kirisako, Komander, Kulathu, Ma, Marshak-Rothstein, Nair, Nurieva, Ordureau, Oshima, Pasare, Peng, Philip Cohen, Plenge, Rachel Toth, Rahighi, Ram K.C. Venigalla, Sambit K. Nanda, Sato, Sato, Schmitt, Shim, Sutmuller, Tavares, Thomson, Tokunaga, Vinuesa, Vinuesa, Wagner, Walsh, Wang, Wertz, Windheim, Windheim, Wu, Xia   +57 more
core   +5 more sources

Activation of GABA_B receptors inhibits protein kinase B /Glycogen Synthase Kinase 3 signaling

Molecular Brain, 2012
Accumulated evidence has suggested that potentiation of cortical GABAergic inhibitory neurotransmission may be a key mechanism in the treatment of schizophrenia. However, the downstream molecular mechanisms related to GABA potentiation remain unexplored.
Lu Frances Fangjia, Su Ping, Liu Fang, Daskalakis Zafiris J   +3 more
doaj   +1 more source

Glutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress
Shuguang Yan, Yi Hui, Jingtao Li, Xiaofan Xu, Qian Li, Hailiang Wei   +5 more
doaj   +1 more source

Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [PDF]

, 2010
The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-
Bravo, Laura, Goya, Luis, Granado-Serrano, Ana Belen, Haegeman, Guy, Martin, Maria Anegeles, Ramos, Sonia   +5 more
core   +3 more sources

NEURODEGENERATION CAUSED BY TRIMETHYLTIN VIA INHIBITION OF TROPOMYOSIN-RECEPTOR-KINASE B AND PHOSPHOINOSITIDE 3-KINASE/PROTEIN KINASE B SIGNALING CASCADE

Indonesian Journal of Pharmacy, 2014
Trimethyltin (TMT, 2.4mg/kg, i.p) can trigger neuronal damage by inhibiting Tropomyosin receptor kinase B (TrkB receptor) following by phosphoinositide 3-kinase (PI3K)/protein kinase B or Akt signaling cascade. We examined hippocampal changes in TrkA/
Tran Phi Hoang Yen, Nguyen Ngoc Khoi, Duong Phuoc An, Nguyen Thi Thu Van, Do Minh Quang   +4 more
doaj   +1 more source

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA). [PDF]

, 1994
The gene responsible for X-linked agammaglobulinemia (XLA) has been recently identified to code for a cytoplasmic tyrosine kinase (Bruton's agammaglobulinemia tyrosine kinase, BTK), required for normal B cell development. BTK, like many other cytoplasmic
Chen, SH, Hagemann, T, Kwan, SP, Nilsson, L, Ochs, HD, Rawlings, DJ, Saffran, DC, Smith, CI, Vihinen, M, Witte, ON, Zhang, M, Zhu, Q   +11 more
core   +1 more source

Interaction between Yeast Cdc6 Protein and B-Type Cyclin/Cdc28 Kinases [PDF]

, 1996
During purification of recombinant Cdc6 expressed in yeast, we found that Cdc6 interacts with the critical cell cycle, cyclin-dependent protein kinase Cdc28.
Campbell, Judith L., Elsasser, Suzanne, Jong, Ambrose, Lou, Feng, Wang, Bin   +4 more
core   +1 more source

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase [PDF]

, 2013
Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying
A Corbould, A Krook, A Krook, AJ Ruiz-Alcaraz, Andrew D. Morris, Antonio J. Ruiz-Alcaraz, C Schmitz-Peiffer, Calum Sutherland, Christopher Lipina, Daniel J. Cuthbertson, DJ Cuthbertson, DJ Cuthbertson, F Tremblay, G Marchesini, GI Shulman, J Jager, J Rung, JA Babraj, John R. Petrie, Jose A. L. Calbet, K Cusi, K Tan, KD Copps, LJ Goodyear, M Friedrichsen, M M, M Rajkhowa, Michael J. Murphy, P Langlais, RA DeFronzo, RA DeFronzo, S George, VT Samuel, YL Woods   +33 more
core   +5 more sources

Effects of Metformin on Cognitive Dysfunction and PI3K/Akt Pathway in Alzheimer's Disease Rats

Shiyan dongwu yu bijiao yixue, 2021
ObjectiveTo investigate the effects of metformin (Met) on the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway and cognitive dysfunction in Alzheimer's disease (AD) rats.MethodsFifty Sprague Dawley rats were selected and divided into ...
WANG Baiqiao, LIN Xiaoru, HAN Min, LIU Yu, TANG Chaoling   +4 more
doaj   +1 more source

Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]

PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv   +1 more source