Results 191 to 200 of about 1,202,909 (308)

Decreased Phosphorylated Protein Kinase B (Akt) in Individuals with Autism Associated with High Epidermal Growth Factor Receptor (EGFR) and Low Gamma-Aminobutyric Acid (GABA)

Biomarker Insights, 2015
Anthony J. Russo
doaj  

[Retracted] Isoflurane reduces pain and inhibits apoptosis of myocardial cells through the phosphoinositide 3‑kinase/protein kinase B signaling pathway in mice during cardiac surgery. [PDF]

Mol Med Rep
Pi Z, Lin H, Yang J.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Treatment strategies targeting the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin pathway against triple-negative breast cancer. [PDF]

World J Clin Oncol
Ni CX, Xu JJ, Pang Y, Xu JJ.
europepmc   +1 more source

Expression Patterns of Aurora Kinase B, Heat Shock Protein 47, and Periostin in Esophageal Squamous Cell Carcinoma

, 2009
Yong-Jae Kwon, Seog Joo Lee, Jae Soo Koh, Sung‐Han Kim, Young‐Joon Kim, Jong Ho Park   +5 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway. [PDF]

World J Stem Cells
Wang LL, Ouyang MY, Yang ZE, Xing SN, Zhao S, Yu HY.   +5 more
europepmc   +1 more source

The Phosphoinositol-3-Kinase–Protein Kinase B/Akt Pathway Is Critical for Pseudomonas aeruginosa Strain PAK Internalization [PDF]

, 2005
Arlinet Kierbel, Ama Gassama‐Diagne, Keith E. Mostov, Joanne N. Engel   +3 more
openalex   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Effects of Huoxue Chubi decoction on protein kinase B-mammalian target of rapamycin autophagy pathway in scleroderma Balb/c model mice. [PDF]

J Tradit Chin Med
Xi C, Tiange QU, Hui J, Xingwu D, Jianhong LI, Kaihui Z, Runtian Z, Ruijie W.   +7 more
europepmc   +1 more source