Results 201 to 210 of about 1,202,909 (308)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the phosphoinositide 3-kinase/protein kinase B signaling pathway. [PDF]

World J Diabetes
Xiong SX, Huang LJ, Liu HS, Zhang XX, Li M, Cui YB, Shao C, Hu XL.   +7 more
europepmc   +1 more source

Elsholtzia ciliatainhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-κB

, 2011
Hui-Hun Kim, Jin-Su Yoo, Hyun‐Shik Lee, Taeg Kyu Kwon, Tae‐Yong Shin, Sang‐Hyun Kim   +5 more
openalex   +2 more sources

Protein kinase B (PKB; Akt); phosphoinositide 3-kinase (PI3K) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Fast detection of protein kinase B in chrysin treated colorectal cancer cells using a novel multicore microfiber biosensor. [PDF]

Commun Eng
Tian Z, Xuan H, Yao Y, Hao S, Zhang Z, Zhang B, Zhang J, Zhang L, Sang X, Yuan J, Farrell G, Wu Q.   +11 more
europepmc   +1 more source

Crystal structure of cGMP‐dependent protein kinase Iβ cyclic nucleotide‐binding‐B domain : Rp‐cGMPS complex reveals an apo‐like, inactive conformation

, 2016
James C. Campbell, Bryan VanSchouwen, Robin Lorenz, Banumathi Sankaran, Friedrich W. Herberg, Giuseppe Melacini, Choel Kim   +6 more
openalex   +2 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation <i>via</i> cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling. [PDF]

World J Gastrointest Oncol
Wang YT, Yong YL, Liu ZK, Shen YX, Yang XM, Chen ZN.   +5 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source