Results 341 to 350 of about 3,162,793 (373)

Regulating Protein Kinase B

Science Signaling, 2001
Protein kinase B (PKB) has proven to be a key regulatory element in growth factor signaling, cell survival, and transformation to a cancerous phenotype. Maira et al. screened for proteins that physically interacted with PKB and identified a human protein, which they call carboxyl-terminal modulator protein (CTMP ...
  +4 more sources

Protein kinases, from B to C

Biochemical Society Transactions, 2007
The PKB (protein kinase B) and PKC (protein kinase C) families display highly related catalytic domains that require a largely conserved series of phosphorylations for the expression of their optimum activities. However, in cells, the dynamics of these modifications are quite distinct.
Cameron, A. J., De Rycker, M., Calleja, V., Alcor, D., Kjaer, S., Kostelecky, B., Saurin, A., Faisal, A., Laguerre, M., Hemmings, B. A., McDonald, N., Larijani, B., Parker, P. J.   +12 more
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Protein Kinase Activity in Hepatitis B Virus

Journal of Virology, 1980
Protein kinase activity was found in hepatitis B virions (Dane particles) purified from the plasma of hepatitis B virus-infected patients, in virion cores, and in hepatitis B core antigen particles purified from hepatitis B virus-infected hepatic tissue and was not found in purified hepatitis B surface antigen particle preparations free of Dane ...
C, Albin, W S, Robinson
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Analysis of Protein Kinase B/Akt

2002
Protein kinase B (PKB or Akt) was initially identified as a serine/threonine kinase with homology to protein kinases A and C, and as an oncoprotein. Three isoforms of PKB have subsequently been identified: PKBα, PKBβ, and PKBγ, which are 80% identical in amino acid sequence, and all contain an N-terminal pleckstrin homology (PH) domain and a C-terminal
Hill, Michelle M., Hemmings, Brian A.
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Physiological functions of protein kinase B/Akt

Biochemical Society Transactions, 2004
The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and ...
Z-Z, Yang, O, Tschopp, A, Baudry, B, Dümmler, D, Hynx, B A, Hemmings   +5 more
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Protein Kinase C and Melanocyte Transformation

Pigment Cell Research, 1988
Melanoma cells which have been isolated from metastatic melanoma tissue are able to survive and proliferate in serum supplemented media. In contrast, normal human melanocytes require the presence of growth stimulators if they are to survive in culture.
MARY BIRCH, F.L. MEYSKENS, MURRAY KORC
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Protein kinase B in the diabetic heart

Molecular and Cellular Biochemistry, 2003
This paper summarizes data from different studies all aimed at elucidating regulation of protein kinase B in the diabetic heart. Two rat models of type 2 diabetes mellitus ((i) elicited via neonatal streptozotocin injection (Stz) and (ii) Zucker fa/fa rats), were used as well as different experimental models viz isolated, Langendorff perfused hearts as
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Protein kinase B: signalling roles and therapeutic targeting

Cellular and Molecular Life Sciences, 2007
The serine/threonine kinase, protein kinase B (PKB, also known as Akt), is activated by a wide array of growth factors and insulin. PKB is a central player in the regulation of metabolism, apoptosis, transcription and the cell-cycle. PKB exists as three isoforms (alpha, beta and gamma) that may have unique as well as common functions within the cell ...
E M, Sale, G J, Sale
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Virtual Docking Approaches to Protein Kinase B Inhibition

Journal of Medicinal Chemistry, 2005
We examined some in silico approaches to identify Akt (protein kinase B) inhibitors. Experimental validation of selected compounds was achieved using a fluorescence-based enzymatic assay and a substrate phosphorylation assay involving the protein GSK-3.
FORINO, MARTINO, D. JUNG, J. B. EASTON, P. J. HOUGHTON, M. PELLECCHIA   +4 more
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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Nature, 1995
D. Cross, D. Alessi, P. Cohen, Mirjana Andjelkovich, B. Hemmings   +4 more
semanticscholar   +1 more source