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Mechanism of activation and function of protein kinase B.
Current Opinion in Genetics and Development, 1998D. Alessi, P. Cohen
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2017
Insulin producing pancreatic ? cells are critical for balancing mammalian metabolism. ? cells are lost or insufficient in Type I diabetes due to autoimmune attack. Similarly, functional impairment and loss of ? cells in Type II diabetic patients promote disease stage to the point when patients must rely on exogenous insulin. ?
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Insulin producing pancreatic ? cells are critical for balancing mammalian metabolism. ? cells are lost or insufficient in Type I diabetes due to autoimmune attack. Similarly, functional impairment and loss of ? cells in Type II diabetic patients promote disease stage to the point when patients must rely on exogenous insulin. ?
openaire +1 more source
Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein*
Journal of Biological Chemistry, 2000S. Pugazhenthi +6 more
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Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
Nature, 1998Shigetoshi Yano +2 more
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Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP
Nature Structural Biology, 2002Jing Yang +5 more
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