Results 121 to 130 of about 2,013,902 (341)

Angiotensin II Directly Triggers Endothelial Exocytosis via Protein Kinase C-Dependent Protein Kinase D2 Activation

Journal of Pharmacological Sciences, 2007
Angiotensin II (AII) has been reported to induce leukocyte adhesion to endothelium through up-regulation of P-selectin surface expression. However, the underlying molecular and cellular mechanisms remain unknown.
Xiaona Ge, Brad Low, Mei Liang, Jian Fu
doaj  

Cell membrane disruption stimulates cAMP and Ca2+ signaling to potentiate cell membrane resealing in neighboring cells

Biology Open, 2017
Disruption of cellular plasma membranes is a common event in many animal tissues, and the membranes are usually rapidly resealed. Moreover, repeated membrane disruptions within a single cell reseal faster than the initial wound in a protein kinase A (PKA)
Tatsuru Togo
doaj   +1 more source

Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE [PDF]

Small molecule drug design hinges on obtaining co-crystallized ligand-protein structures. Despite AlphaFold2's strides in protein native structure prediction, its focus on apo structures overlooks ligands and associated holo structures. Moreover, designing selective drugs often benefits from the targeting of diverse metastable conformations. Therefore,
arxiv   +1 more source

Protein kinase C and alcohol addiction

Pharmacological Research, 2007
Alcohol abuse and addiction are serious global health problems. Tackling these disorders requires an understanding of how ethanol produces its effects. Early cell culture studies implicated the protein kinase C (PKC) family of serine-threonine kinases in mediating both acute and chronic responses to ethanol exposure.
Dorit Ron, Philip M. Newton
openaire   +5 more sources

Modulation of cardiac Ca2+ channels in Xenopus oocytes by protein kinase C [PDF]

, 1992
L-Type calcium channel was expressed in Xenopus laevis oocytes injected with RNAs coding for different cardiac Cu2+ channel subunits, or with total heart RNA.
Biel, Biel, Bosse, Bourinet, Catterall, Catterall, Chang, Chang, Chang, Dafna Singer-Lahat, Dascal, Dascal, Dascal, Dascal, Dascal, Dosemeci, Eli Gershon, Ellis, Fenwick, Franz Hofmann, Glossmann, Gutierrez, Guy, Hofmann, Hullin, Ilana Lotan, Itagaki, Jay, Lacerda, Lory, Lotan, Martin Biel, Mikami, Mori, Morton, Nastainczyk, Nathan Dascal, O'Callahan, O'Callahan, Perez-Reyes, Perez-Reyes, Reuter, Roger Hullin, Ruth, Shearman, Sieber, Singer, Tanabe, Trautwein, Tseng, Tsien, Varadi, Vasilets, Veit Flockerzi, Williams   +54 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

d-α-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells [PDF]

, 1993
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity.
Özer, N.K., Palozza, P., Boscoboinik, D., Azzi, A.   +3 more
core   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Characterization of the binding and phosphorylation of cardiac calsequestrin by ɛ protein kinase C [PDF]

In this study, we report the cloning of the rat cardiac isoform of calsequestrin on the basis of its interaction with an ɛprotein kinase C-unique sequence (ɛV1) derived from the ɛprotein kinase C regulatory domain.
Chen, Che-Hong, Mochly-Rosen, Daria, Rodriguez, Manuel M., Smith, Bradly L.   +3 more
core   +1 more source

Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. [PDF]

, 2015
GABAA receptors are important for inhibition in the CNS where neurosteroids and protein kinases are potent endogenous modulators. Acting individually, these can either enhance or depress receptor function, dependent upon the type of neurosteroid or ...
Adams, JM, Smart, TG, Thomas, P
core   +1 more source