Results 91 to 100 of about 843,778 (210)

Unlocking the therapeutic potential of protein kinase inhibitors in neurodegenerative and psychiatric disorders [PDF]

Exploration of Drug Science
Protein phosphorylation is a fundamental regulatory mechanism governing a broad spectrum of cellular processes. In the nervous system, it is critical for modulating neurotransmitter release, synaptic plasticity, neuronal excitability, and cell survival ...
Angela Asir R V, Polina Buzaeva, Izhak Michaelevski   +2 more
doaj   +1 more source

Alzheimer's disease pathology and the unfolded protein response : Prospective pathways and therapeutic targets [PDF]

, 2017
The authors would like to thank Alzheimer's Research UK (Grant refs: ARUK-PPG2014A-21 and ARUK-NSG2015-1 to BP and DK) who have provided support for relevant projects leading to this review.Peer ...
Koss, David J, Platt, Bettina
core   +1 more source

Current Development Status of MEK Inhibitors

Molecules, 2017
The current development status of mitogen-activated protein kinase kinase (MEK) inhibitors, including the preclinical data and clinical study progress, has been summarized in this review.
Ying Cheng, Hongqi Tian
doaj   +1 more source

A General Framework for Inhibitor Resistance in Protein Kinases

Chemistry & Biology, 2011
Protein kinases control virtually every aspect of normal and pathological cell physiology and are considered ideal targets for drug discovery. Most kinase inhibitors target the ATP binding site and interact with residue of a hinge loop connecting the small and large lobes of the kinase scaffold.
Balzano, Deborah, Santaguida, Stefano, Musacchio, Andrea, Villa, Fabrizio   +3 more
openaire   +3 more sources

Pharmacology Of Protein Kinase Inhibitors

Annual Review of Pharmacology and Toxicology, 1992
Ryoji Kobayashi, Hiroyoshi Hidaka
openaire   +5 more sources

Systematic Analysis of Covalent and Allosteric Protein Kinase Inhibitors. [PDF]

Molecules, 2023
Xerxa E, Laufkötter O, Bajorath J.
europepmc   +1 more source

Structure-based design and activity modeling of novel epidermal growth factor receptor kinase inhibitors; an in silico approach

Scientific African, 2020
The development of EGFR kinase inhibitors to treat non-small cell lung cancers is an important medical necessity due to persistent development of resistance by the mutations.
Muhammad Tukur Ibrahim, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba   +3 more
doaj  

Targeting autophagy-related protein kinases for potential therapeutic purpose

Acta Pharmaceutica Sinica B, 2020
Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles.
Honggang Xiang, Jifa Zhang, Congcong Lin, Lan Zhang, Bo Liu, Liang Ouyang   +5 more
doaj  

Novel Serine-Arginine Protein Kinase Inhibitors for Treating Cancer. [PDF]

ACS Med Chem Lett, 2023
Sabnis RW.
europepmc   +1 more source

Hepatotoxicity of Small Molecule Protein Kinase Inhibitors for Cancer. [PDF]

Cancers (Basel), 2023
Viganò M, La Milia M, Grassini MV, Pugliese N, De Giorgio M, Fagiuoli S.   +5 more
europepmc   +1 more source