Results 101 to 110 of about 843,778 (210)

Critical analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany. [PDF]

Naunyn Schmiedebergs Arch Pharmacol, 2023
Obst CS, Seifert R.
europepmc   +1 more source

Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning ApproachResearch in context

EBioMedicine, 2018
Background: Cdc7-Dbf4 is a conserved serine/threonine kinase that plays an important role in initiation of DNA replication and DNA damage tolerance in eukaryotic cells.
An Ning Cheng, Yu-Kang Lo, Yi-Sheng Lin, Tswen-Kei Tang, Chun-Hua Hsu, John T.-A. Hsu, Alan Yueh-Luen Lee   +6 more
doaj  

Medicinal chemistry breakthroughs on ATM, ATR, and DNA-PK inhibitors as prospective cancer therapeutics

Journal of Enzyme Inhibition and Medicinal Chemistry
This review discusses the critical roles of Ataxia Telangiectasia Mutated Kinase (ATM), ATM and Rad3-related Kinase (ATR), and DNA-dependent protein kinase (DNA-PK) in the DNA damage response (DDR) and their implications in cancer.
Ram Sharma, Anshul Mishra, Monika Bhardwaj, Gurpreet Singh, Larasati Vanya Indira Harahap, Sakshi Vanjani, Chun Hsu Pan, Kunal Nepali   +7 more
doaj   +1 more source

Data sets of human and mouse protein kinase inhibitors with curated activity data including covalent inhibitors. [PDF]

Future Sci OA, 2023
Xerxa E, Bajorath J.
europepmc   +1 more source

Role and mechanistic actions of protein kinase inhibitors as an effective drug target for cancer and COVID. [PDF]

Arch Microbiol, 2023
Narayanan J, Tamilanban T, Kumar PS, Guru A, Muthupandian S, Kathiravan MK, Arockiaraj J.   +6 more
europepmc   +1 more source

Evaluating the ability of end-point methods to predict the binding affinity tendency of protein kinase inhibitors. [PDF]

RSC Adv, 2023
Bello M, Bandala C.
europepmc   +1 more source

Editorial: Recent advances in the research and development of kinase-inhibitory anticancer molecules

Frontiers in Chemistry, 2023
Ahmed A. Al-Karmalawy, Ahmed A. Al-Karmalawy, Hussein I. El-Subbagh, Hussein I. El-Subbagh, Liliya Logoyda, Roman B. Lesyk, Mohammed I. El-Gamal, Mohammed I. El-Gamal, Mohammed I. El-Gamal   +8 more
doaj   +1 more source

Revisiting p38 Mitogen-Activated Protein Kinases (MAPK) in Inflammatory Arthritis: A Narrative of the Emergence of MAPK-Activated Protein Kinase Inhibitors (MK2i). [PDF]

Pharmaceuticals (Basel), 2023
Ganguly P, Macleod T, Wong C, Harland M, McGonagle D.   +4 more
europepmc   +1 more source

Novel 7-Deazapurine Incorporating Isatin Hybrid Compounds as Protein Kinase Inhibitors: Design, Synthesis, In Silico Studies, and Antiproliferative Evaluation. [PDF]

Molecules, 2023
Alanazi MM, Alanazi AS.
europepmc   +1 more source

Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management. [PDF]

Int J Mol Sci, 2022
Filippone A, Mannino D, Casili G, Lanza M, Paterniti I, Cuzzocrea S, Capra AP, Colarossi L, Giuffrida D, Lombardo SP, Esposito E.   +10 more
europepmc   +1 more source