Results 171 to 180 of about 2,078,021 (401)

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Medicinal chemistry breakthroughs on ATM, ATR, and DNA-PK inhibitors as prospective cancer therapeutics

Journal of Enzyme Inhibition and Medicinal Chemistry
This review discusses the critical roles of Ataxia Telangiectasia Mutated Kinase (ATM), ATM and Rad3-related Kinase (ATR), and DNA-dependent protein kinase (DNA-PK) in the DNA damage response (DDR) and their implications in cancer.
Ram Sharma, Anshul Mishra, Monika Bhardwaj, Gurpreet Singh, Larasati Vanya Indira Harahap, Sakshi Vanjani, Chun Hsu Pan, Kunal Nepali   +7 more
doaj   +1 more source

Data sets of human and mouse protein kinase inhibitors with curated activity data including covalent inhibitors. [PDF]

Future Sci OA, 2023
Xerxa E, Bajorath J.
europepmc   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Editorial: Recent advances in the research and development of kinase-inhibitory anticancer molecules

Frontiers in Chemistry, 2023
Ahmed A. Al-Karmalawy, Ahmed A. Al-Karmalawy, Hussein I. El-Subbagh, Hussein I. El-Subbagh, Liliya Logoyda, Roman B. Lesyk, Mohammed I. El-Gamal, Mohammed I. El-Gamal, Mohammed I. El-Gamal   +8 more
doaj   +1 more source

Role and mechanistic actions of protein kinase inhibitors as an effective drug target for cancer and COVID. [PDF]

Arch Microbiol, 2023
Narayanan J, Tamilanban T, Kumar PS, Guru A, Muthupandian S, Kathiravan MK, Arockiaraj J.   +6 more
europepmc   +1 more source

The protein kinase C inhibitor 1‐(5‐isoquinolinesulphonyl)‐2‐methylpiperazine (H‐7) disinhibits CA1 pyramidal cells in rat hippocampal slices [PDF]

, 1989
Renato Corradetti, Anna Maria Pugliese, Nicole Ropert   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Evaluating the ability of end-point methods to predict the binding affinity tendency of protein kinase inhibitors. [PDF]

RSC Adv, 2023
Bello M, Bandala C.
europepmc   +1 more source

SAR Studies on the Inhibitors for the Treatment of Inflammatory Diseases [PDF]

, 2016
School of Molecular Sciences(Chemistry)Inflammation is defensive host response that occurs from infection and injury and the inflammatory process is the pivotal physiological response of our body and essential part of the human physiology.
Kim, Min-Jeong
core