Results 171 to 180 of about 843,778 (210)

Rottlerin, a Novel Protein Kinase Inhibitor

Biochemical and Biophysical Research Communications, 1994
Rottlerin, a compound from Mallotus philippinensis, is shown to inhibit protein kinases with some specificity for PKC. To some extent, the novel inhibitor is able to differentiate between PKC isoenzymes, with IC50 values for PKC delta of 3-6 microM, PKC alpha,beta,gamma of 30-42 microM and PKC epsilon,eta,zeta of 80-100 microM.
Friedrich Marks, Walter Kittstein, H.J. Muller, Michael Gschwendt, Gabriele Rincke, R. Zang, K. Kielbassa   +6 more
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Chemical Inhibitors of Protein Kinases

Chemical Reviews, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +4 more sources

Profiling of inhibitors of protein kinase C

Advances in Enzyme Regulation, 1988
A rapid screen assay for protein kinase C was described which allowed the detection of inhibitors and activators of the enzyme at different states of activation. Upon secondary evaluation of the active inhibitors, three classes of compounds were identified.
Halyna E. Wysowskyj, Lawrence P. Wennogle, Arco Y. Jeng   +2 more
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Ruthenium Complexes as Protein Kinase Inhibitors

Organic Letters, 2004
[reaction: see text] Replacing complex natural products with simple metal complexes could lead to a new class of metallopharmaceuticals in which the metal center plays mainly a structural role. A strategy is introduced for the creation of ruthenium complex-based protein kinase inhibitors 1 (X = CO or CH(2)), morphed out of the class of indolocarbazole ...
Patrick J. Carroll, Eric Meggers, Lilu Zhang   +2 more
openaire   +3 more sources

Protein kinase inhibitors and antibiotic resistance

Pharmacology & Therapeutics, 2002
While antibiotics revolutionized the treatment of infectious disease in the 20th century, bacterial resistance now threatens to render many of them ineffective. Aminoglycosides are a class of clinically important antibiotics used in the treatment of infections caused by Gram-positive and -negative organisms.
Albert M. Berghuis, David L. Burk
openaire   +3 more sources

The Protein Kinase C Inhibitor: Ruboxistaurin

2015
The isozyme protein kinase C (PKC) β is involved in several processes that are deregulated in different retinal cell types by hyperglycemia. This family of serine/threonine-specific protein kinases comprises several different members, which differ in their structure, cofactor requirement and substrate specificity.
Gabriele E. Lang, Heidrun L. Deissler
openaire   +2 more sources

Inhibitors of Protein KinasesCGP 41251, a Protein Kinase Inhibitor with Potential as an Anticancer Agent

Pharmacology & Therapeutics, 1999
CGP 41251 was originally identified as an inhibitor of protein kinase C (PKC), inhibiting mainly the conventional PKC subtypes, and subsequently shown to inhibit the vascular endothelial growth factor (VEGF) receptor kinase insert domain-containing receptor, which is involved in angiogenesis.
Thomas Meyer, Doriano Fabbro, Francesco Hofmann, Jürgen Mestan, Helmut Mett, Stefano Ferrari, Jeannette Wood, Elisabeth Buchdunger, Terence O'reilly   +8 more
openaire   +3 more sources

Novel mitogen-activated protein kinase kinase inhibitors

Expert Opinion on Investigational Drugs, 2011
the development of new drugs over the last few decades has targeted specific proteins thought to be a key to the disease state. MAPK kinases 1 and 2 (commonly known as MEK1-2) represent such proteins as they lie downstream of important drug targets for oncology, such as EGFR, RAS and RAF.
Jeffrey N. Miner, Mark S. Chapman
openaire   +3 more sources

Physiological inhibitors of protein kinase C

Biochemical Pharmacology, 1996
Increasing numbers of proteins that have the capacity of interacting with protein kinase C isozymes in vitro and inhibiting their enzymatic activity in a noncompetitive manner have been purified. While these proteins can be hypothesized to be part of a tight regulatory system for protein kinase C enzymatic activity, critical examinations of the roles ...
openaire   +3 more sources

ChemInform Abstract: Metal Complexes as Protein Kinase Inhibitors

ChemInform, 2010
AbstractReview: iridium complexes; 13 refs.
Conrad Kunick, Ingo Ott
openaire   +4 more sources