Results 221 to 230 of about 2,154,176 (393)

Development and Evolution of DNA-Dependent Protein Kinase Inhibitors toward Cancer Therapy. [PDF]

Int J Mol Sci, 2022
Matsumoto Y.
europepmc   +1 more source

Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C [PDF]

, 1990
John A. Johnson, R B Clark
openalex   +1 more source

Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity

, 2022
Krikor Bijian, Dominik Wernic, Anita Karen Nivedha, Jie Su, Felicia Phei Lin Lim, Caitlin E. Miron, Hind Amzil, Nicolas Moitessier, Moulay A. Alaoui‐Jamali   +8 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Advances in pyrazolo[1,5-a]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment. [PDF]

RSC Adv
Iorkula TH, Jude-Kelly Osayawe O, Odogwu DA, Ganiyu LO, Faderin E, Awoyemi RF, Akodu BO, Ifijen IH, Aworinde OR, Agyemang P, Onyinyechi OL.   +10 more
europepmc   +1 more source

Synthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors. [PDF]

Med Chem Res, 2022
Gnawali GR, Okumura K, Perez K, Gallagher R, Wulfkuhle J, Petricoin EF, Padi SKR, Bearss J, He Z, Wang W, Kraft AS.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Editorial: Targeting cellular signalling pathways for disease therapy: the potential of cellular reprogramming and protein kinase inhibitors. [PDF]

Front Pharmacol
Marensi V, Oliveira PF, Zamoner A.
europepmc   +1 more source

Src-Family Protein Kinase Inhibitors Suppress MYB Activity in a p300-Dependent Manner. [PDF]

Cells, 2022
Biyanee A, Yusenko MV, Klempnauer KH.
europepmc   +1 more source

Endogenous Protein Kinase Inhibitor γ Terminates Immediate-early Gene Expression Induced by cAMP-dependent Protein Kinase (PKA) Signaling [PDF]

, 2004
Xin Chen, Jia-Chun Dai, Stephanie A. Orellana, Edward M. Greenfield   +3 more
openalex   +1 more source