Results 251 to 260 of about 2,154,176 (393)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Oncotherapeutic Protein Kinase Inhibitors Associated With Pro-Arrhythmic Liability. [PDF]

JACC CardioOncol, 2021
Ye JZ, Hansen FB, Mills RW, Lundby A.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Editorial: Protein kinase inhibitors in neurodegeneration and cancer targeted therapies. [PDF]

Front Cell Dev Biol
Anwar S, Ahmed A, Sarli V, Hassan I.
europepmc   +1 more source

Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis. [PDF]

Molecules, 2022
Pereira Moreira B, Weber MHW, Haeberlein S, Mokosch AS, Spengler B, Grevelding CG, Falcone FH.   +6 more
europepmc   +1 more source

Mitogen-Activated Protein Kinase Kinase Inhibitor [PDF]

, 2020
openaire   +1 more source

Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages [PDF]

, 2015
Mingyue Wen, Xianwei Ma, Hong Cheng, Wei Jiang, Xiongfei Xu, Yi Zhang, Yan Zhang, Zhenhong Guo, Yizhi Yu, Hongmei Xu, Cheng Qian, Xuetao Cao, Huazhang An   +12 more
openalex   +1 more source

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

Nature Structural &Molecular Biology, 2010
K. Ojo, E. Larson, K. Keyloun, L. Castaneda, A. DeRocher, Krishna K Inampudi, Jessica E. Kim, T. Arakaki, R. C. Murphy, Li Zhang, A. Napuli, Dustin J Maly, C. Verlinde, F. Buckner, M. Parsons, W. Hol, E. Merritt, W. V. Voorhis   +17 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Design, Synthesis, and Cytotoxicity Evaluation of Novel Indolin-2-One Based Molecules on Hepatocellular Carcinoma HepG2 Cells as Protein Kinase Inhibitors. [PDF]

Molecules
Kandeel MM, AbdElhameid MK, Adel M, Al-Shorbagy MY, Negmeldin AT.   +4 more
europepmc   +1 more source