Results 261 to 270 of about 2,154,176 (393)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

[Retracted] Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: A rationale to combine targeted drugs based on protein expression inhibition profiles. [PDF]

Int J Oncol
Aftimos PG, Wiedig M, Fontsa ML, Awada A, Ghanem G, Journe F.   +5 more
europepmc   +1 more source

Wogonin inhibits Varicella-Zoster (shingles) virus replication via modulation of type I interferon signaling and adenosine monophosphate-activated protein kinase activity

, 2015
Eun-Jin Choi, Chan‐Hee Lee, Youn-Chul Kim, Ok Sarah Shin   +3 more
openalex   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Molecular Mechanisms of Alzheimer's Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy. [PDF]

Cells
Ahn EH, Park JB.
europepmc   +1 more source

Sphingosine kinase inhibitor suppresses dendritic cell migration by regulating chemokine receptor expression and impairing p38 mitogen‐activated protein kinase

, 2007
In Duk Jung, Jun Sik Lee, Yong‐Joo Kim, Young‐Il Jeong, Chang‐Min Lee, Min Goo Lee, Soon‐Choel Ahn, Yeong‐Min Park   +7 more
openalex   +1 more source

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1 [PDF]

, 2014
T.J. Rettenmaier, Jack Sadowsky, N.D. Thomsen, Steven C. Chen, Allison K. Doak, Michelle R. Arkin, James A. Wells   +6 more
openalex   +1 more source

Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.

Journal of the American Chemical Society, 2011
Li Feng, Y. Geisselbrecht, S. Blanck, Alexander Wilbuer, G. Atilla‐Gokcumen, P. Filippakopoulos, Katja Kräling, Mehmet Ali Celik, K. Harms, J. Maksimoska, R. Marmorstein, G. Frenking, S. Knapp, L. Essen, E. Meggers   +14 more
semanticscholar   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Small-molecule protein kinase inhibitors and their effects on the immune system: implications for cancer treatment.

Immunotherapy, 2011
P. Ott, S. Adams
semanticscholar   +1 more source