Results 291 to 300 of about 2,078,021 (401)

Neurotrophic Effects of Epidermal Growth Factor on Cultured Brain Neurons Are Blocked by Protein Kinase Inhibitors

, 1992
Kazuho Abe, Megumi Takayanagi, Hiroshi Saitō   +2 more
openalex   +1 more source

Small-molecule protein kinase inhibitors and their effects on the immune system: implications for cancer treatment.

Immunotherapy, 2011
P. Ott, S. Adams
semanticscholar   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

Calphostin C, a Potent and Specific Inhibitor of Protein Kinase C, Reduces Phorbol Ester-Induced but Not Primary Ca2+-Induced Catecholamine Secretion from Digitonin-Permeabilized Bovine Adrenal Medullary Cells

, 1994
Minoru Isosaki, Naoki Minami, Toshikatsu Nakashima   +2 more
openalex   +1 more source

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

Circulation, 2011
Wei Wu, A. Muchir, J. Shan, G. Bonne, H. Worman   +4 more
semanticscholar   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

ACTIVATION OF PROTEIN KINASE C INHIBITS NaF-INDUCED INOSITOLPHOSPHOLIPID TURNOVER IN ISOLATED CANINE PARIETAL CELLS

, 1991
Tsutomu Chiba, Akira Nakamura, Toshiyuki Yamatani, Takuo Fujita   +3 more
openalex   +2 more sources

Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno‐Free Cultures of Human Adipose Tissue‐Derived Stem Cells

Advanced Biology, EarlyView.
The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo, Anne Therese Lauvrud, Rebecca Wiberg, Maria Brohlin, Gustav Andersson, Paul J Kingham   +5 more
wiley   +1 more source

Study on KN-93, a newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor and its effects on catecholamine metabolism in PC12h cells

, 1992
Mariko Sumi, Kazutoshi Kiuchi, Tomohiko Ishikawa, Akira Ishii, Masatoshi Hagiwara, Toshiharu Nagatsu, Hiroyoshi Hidaka   +6 more
openalex   +1 more source

Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors.

Organometallics, 2011
S. Blanck, Thomas Cruchter, A. Vultur, Radostan Riedel, K. Harms, M. Herlyn, E. Meggers   +6 more
semanticscholar   +1 more source